Development and Validation of UV Spectrophotometric Area Under Curve (AUC) method for estimation of Pyrantel Pamoate in Bulk and Tablet Dosage Form
Journal Title: International Journal of Interdisciplinary and Multidisciplinary Studies (IJIMS) - Year 2014, Vol 1, Issue 7
Abstract
The aim of present work was to develop an accurate, precise, reproducible and economical UV spectrophotometric method for estimation of Pyrantel Pamoate. This method was based on Area Under Curve (AUC) of UV spectrum between 231 to 241 nm and validated as per ICH guideline Q2 (R1). The method is linear in the range of 1.5-3.5 µg/ml. The value of correlation coefficient is 0.999. Values of % relative standard deviation (%RSD) for the intra-day and inter-day precision indicated that method is precise. Results of the recovery studies (99.94 %) showed accuracy of the method. LOD and LOQ were calculated as 0.017µg/ml and 0.0541µg/ml respectively. The developed method can be used for routine estimation of Pyrantel Pamoate in bulk and tablet dosage forms.
Authors and Affiliations
Rahul S. Kommawar and Madhuri A. Nagras
Keywords
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