DEVELOPMENT AND VALIDATION OF UV-SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF TELMISARTAN AND ATORVASTATIN CALCIUM IN BULK AND TABLET DOSAGE FORM
Journal Title: International Journal of Pharmacy and Technology - Year 2010, Vol 2, Issue 2
Abstract
An UV spectrophotometric method using simultaneous equation was developed for the simultaneous determination of Telmisartan and Atorvastatin calcium in a binary mixture. In the proposed method, the signals were measured at 296.0 nm and 247.0 nm corresponding to absorbance maxima of Telmisartan and Atorvastatin Calcium in methanol respectively. Linearity range was observed in the concentration range of 5-30 μg/ml for both the drugs. Concentration of each drug was obtained by using the absorptivity values calculated for both drugs at two wavelengths, 296.0 nm and 247.0 nm and solving the simultaneous equation. Developed method was applied to laboratory mixture and its pharmaceutical formulation. The method was validated tatistically and recovery study was performed to confirm the accuracy of the method. The method was found to be rapid, simple, accurate and precise.
Authors and Affiliations
K. Chaudhari
Keywords
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- EP ID EP144877
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