DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF LOSARTAN BULK DRUG AND PHARMACEUTICAL FORMULATION
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 5
Abstract
Method validation is the process by which it is established that performance characteristics of the method meet the requirements for the intended analytical applications. Methods need to be validated or revalidated before their introduction into routine use. The current aim of the research work was to establish a simple, rapid and inexpensive method for the estimation of losartan. The parameters linearity, precision, accuracy, limit of detection and limit of quantitation were studied according to International Conference on Harmonization guidelines. UV spectroscopic determination was carried out at an absorption maximum of 237 nm using distilled water as solvent. In the UV spectroscopic method linearity over the concentration range of losartan was found to be 6-20 µg/ml with a correlation coefficient 0.990. Results of the analyses were validated statistically and by recovery studies. The proposed method is simple, rapid, precise and accurate and can be used for the reliable quantitation of Losartan in pharmaceutical formulation.
Authors and Affiliations
Pranshu Tangri , Prem Singh , Lakshmayya , Sayantan Mukhopadhyay , Shaffi Tangri
Keywords
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