FORMULATION AND EVALUATION OF MATRIX TYPE TRANSDERMAL SYSTEM OF LISINOPRIL DIHYDRATE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 6
Abstract
Lisinopril is a drug of class angiotensin converting enzyme (ACE) inhibitor that is primarily used in treatment of hypertension, congestive heart failure, heart attacks and also in preventing renal and retinal complications of diabetes. If it is given orally, there may be severe hepatic first pass metabolism as a result there is reduction in the bioavailability (6-60%). In order to increase the bioavailability of the lisinopril, transdermal films were formulated using different polymer combinations such as hydrophilic (hydroxy propyl methyl cellulose: poly vinyl pyrrolidone) and combination of lipophillic- hydrophilic polymers (ethyl cellulose: poly vinyl pyrrolidone) in different ratios. The prepared films were evaluated for thickness, folding endurance, drug content uniformity, tensile strength, percent moisture uptake, percent moisture loss, in-vitro skin permeation study. In-vitro drug release study through sigma membrane indicated that hydrophilic polymer combinations have shown greater drug release than the hydrophilic-lipophillic polymer combinations. By fitting the data into zero order, first order and Higuchi model, it was concluded that drug release from matrix films followed Higuchi model and the mechanism of release was diffusion mediated.
Authors and Affiliations
Suchetha Reddy, Aman Kant, Nagendra Rao, Nagesh. C
Keywords
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