DEVELOPMENT AND VALIDATION OF VISIBLE SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF AMOXYCILLIN TRIHYDRATE IN PHARMACEUTICAL DOSAGE FORM
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 9
Abstract
A simple, sensitive, accurate, precise and economical visible spectrophotometric method was developed and validated for the estimation of amoxycillin trihydrate in tablets. The method is based on the reaction of amoxycillin trihydrate with ninhydrin reagent in methanol giving blue color chromogen, which shows maximum absorbance at 578 nm against reagent blank. The chromogen obeyed Beer’s law in the concentration range of 10-80 µg/ml for amoxycillin trihydrate. The results of the analysis have been validated statistically and by recovery studies.
Authors and Affiliations
Satish Patel , Natavarlal Patel
Keywords
Related Articles
- EP ID EP129927
- DOI -
- Views 92
- Downloads 0
FACTORS AFFECTING PHARMACOKINETIC DISPOSITION OF DRUGS
Absorption of drugs from the gastrointestinal tract is a complex process the variability of which is influenced by many physicochemical and physiologic factors. The two most important physicochemical factors that affect...
EVALUATION OF LOCOMOTOR AND DIURETIC ACTIVITIES OF AQUEOUS AND ALCOHOLIC EXTRACTS OF LEAVES OF EPIPREMNUM AUREUM L.
The aim of the present study was to evaluate the locomotor and diuretic activities of both aqueous and alcoholic extracts of leaves of Epipremnum aureum (AQEEa and ALEEa) in experimental animals. Locomotor activity was e...
IN-VITRO COMPARATIVE STUDY OF CEFOPERAZONE, CEFTAZIDIME, CEFTIZOXIME, CEFOTAXIME, CEFTRIAXONE AND CEFIXIME AGAINST PSEUDOMONAS AERUGINOSA
The prime intention of this study was the evaluation & accumulation of epidemiological data on the resistance of Pseudomonas aeruginosa, and to compare the activity of different third generation cephalosporins agains...
DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF DIAZEPAM AND PROPRANOLOL HYDROCHLORIDE IN COMBINED DOSAGE FORM
The present manuscript describe simple, sensitive, rapid, accurate, precise and economical first derivative spectrophotometric method for the simultaneous determination of diazepam and propranolol hydrochloride in combin...
FORMULATION AND EVALUATION OF NIFEDIPINE SUSTAINED RELEASE PELLETS
Nifedipine is a dihydropyridine derivative effectively used in management of various cardio vascular diseases in long-term therapy. The main objective of this work is formulation of Nifedipine sustained release capsules....