Development and validation of zero and first-order derivative area under curve spectrophotometric methods for the determination of aripiprazole in bulk material and tablets
Journal Title: International Journal of Pharmaceutical Chemistry and Analysis - Year 2018, Vol 5, Issue 1
Abstract
The proposed experiments explain simple precise specific and accurate UV spectrophotometry methods for the estimation of Aripiprazole in bulk and pharmaceutical formulation Aripiprazole is a recent second generation atypical antipsychotic drug used for the treatment of schizophrenia four simple UV spectrophotometric methods were established for estimation of Aripiprazole using double beam UV spectrophotometer UV2450 Shimadzu Japan Aripiprazole showed maximum absorbance lambda max at 255 nm in methanolic HCl as a solvent The calibration curve obeyed BeerLambert law in the concentration range of 5 30 mugmL The recovery was found to be in the range of 98 100 Precision value less than 2 in terms of RSD indicates precise nature of developed methods Validation of developed methods was carried out as per ICH guidelines It was concluded that the results and statistical analysis amongst all four methods AUC method is most simple accurate precise and specific All four methods can be used for routine analysis of Aripiprazole in bulk and pharmaceutical formulationsKeywords Aripiprazole UVSpectrophotometry Derivatives Methods Area Under Curve Method
Authors and Affiliations
Mohammad Faizan S Deshmukh, Mohammad Mujeeb G Khan, Sandip D. Firke, Atul A. Shirkhedkar
Keywords
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- EP ID EP481423
- DOI 10.18231/2394-2797.2018.0005
- Views 72
- Downloads 0
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