DEVELOPMENT OF ACID–BASE TITRIMETRIC METHOD FOR DETERMINATION OF SILDENAFIL CITRATE IN BULK AND TABLETS FORMS
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2018, Vol 7, Issue 7
Abstract
A simple acid –base titrimetric method was developed for the determination of Sildenafil citrate (SC) in bulk and tablet dosage forms. The method was based on titration of SC against 0.01MNaOH using phenolphthalein as indicator. The method was validated with respect to the linearity, precision and accuracy. Calibration curve was found to be linear (r= 0.999) in a range of 5-25mg. The repeatability and inter-day precision were of RSD% values 1.01 and 0.47, respectively. The accuracy of the method was confirmed by the obtained recovery % values (99.7, 99.9 and 100.3 for levels of 50%, 100% and 150%, n=3).
Authors and Affiliations
Mohamed E. Adam
Keywords
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