DEVELOPMENT OF ACID–BASE TITRIMETRIC METHOD FOR DETERMINATION OF SILDENAFIL CITRATE IN BULK AND TABLETS FORMS
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2018, Vol 7, Issue 7
Abstract
A simple acid –base titrimetric method was developed for the determination of Sildenafil citrate (SC) in bulk and tablet dosage forms. The method was based on titration of SC against 0.01MNaOH using phenolphthalein as indicator. The method was validated with respect to the linearity, precision and accuracy. Calibration curve was found to be linear (r= 0.999) in a range of 5-25mg. The repeatability and inter-day precision were of RSD% values 1.01 and 0.47, respectively. The accuracy of the method was confirmed by the obtained recovery % values (99.7, 99.9 and 100.3 for levels of 50%, 100% and 150%, n=3).
Authors and Affiliations
Mohamed E. Adam
Keywords
Related Articles
- EP ID EP627419
- DOI -
- Views 164
- Downloads 0
REVIEW ON RUTA GRAVEOLENS
Bioassay-directed isolation of antifungal compounds from an ethyl acetate extract of Ruta graveolens leaves yielded two furanocoumarins, one quinoline alkaloid, and four quinolone alkaloids including a novel compound, 1-...
ENHANCING THE INTESTINAL ABSORPTION OF METFORMIN MOLECULE VIA HPEPT1 TRANSPORTERS
Type II diabetes mellitus (DM) is a chronic metabolic disorder with an increasing global prevalence and incidence. It is characterized by raised blood glucose levels as a result of insulin resistance and/ or pancreatic b...
DEVELOPMENT AND VALIDATION OF A UPLC METHOD FOR SIMULTANEOUS QUANTIFICATION OF DICLOFENAC POTASSIUM AND CHLORZOXAZONE IN THEIR BINARY MIXTURES AND PHARMACEUTICAL FORMULATION
A simple, precise, accurate and rapid isocratic reverse phase Ultra high performance liquid chromatographic method was developed for simultaneous determination of diclofenac potassium and chlorzoxazone in binary mixture...
COMPARATIVE ASSESSMENT OF ANTIBIOTIC PRODUCTION AND ACTIVITY BY BATCH CULTURES OF STREPTOMYCES SPECIES ISOLATED FROM SOIL UNDER SOLID-STATE AND SUBMERGED FERMENTATIONS.
Antibiotic producing Streptomyces species were isolated by spread.- plating aliquots of tenfold serially diluted pre-treated soil samples on a chemically defined complex Streptomyces isolation medium, ISP1, by the crowde...
AN OVERVIEW ON NOVEL TRENDS IN ORALLY MOUTH DISSOLVING TABLET
Novel drug delivery systems are becoming increasingly sophisticated as pharmaceutical scientists acquire a better understanding of the physicochemical and bio-chemical parameters pertinent to their performance. Fast diss...