DEVELOPMENT OF DICLOFENAC SODIUM MATRIX TABLETS EMPLOYING KOLLIDON SR AND PEG 6000 FOR COLON TARGETTED DRUG DELIVERY
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2017, Vol 7, Issue
Abstract
Abstract The Matrix Tablets each containing 50 mg of diclofenac sodium are prepared employing kollidonSR by direct compression method. The hardness of the tablets was in the range of 6-7kg/sq.cm. Weight loss in friability test was less than 0.3% in all the cases. All the matrix tablets prepared contained 100 ± 2.3% of the labelled claim. All the tablets were found to be non-disintegrating in acidic (pH1.2) and alkaline (pH 7.4) fluids. As such, the prepared tablets were of good quality with respect to drug content, hardness and friability. As the tablets formulated were non- disintegrating in acidic and alkaline fluids, they are considered suitable for colon targeting. From the drug release study it may be concluded that the (DK2) P2 formula of diclofenac sodium matrix tablets have given the desired release profile by showing a minimal release during the lag period of 5 hrs and complete release at the end of 12 hrs. The tablets having the optimised formula (DK2) P2, having 25% kollidonSR with 5% of channelling agent (PEG 6000) showed minimal release of 46% in the lag period of 5 hours and 99.6 % of the drug was released y the end of 12hours. The diclofenac sodium matrix tablets formulated by employing kollidonSR and channelling agent showed non-fickian diffusion mechanism and following zero order kinetics. The optimized formula (DK2) P2 follows Supercase II transport as mechanism for drug release and it follows zero order kinetics. Matrix tablets (DK2) P2 formulated employing 25% kollidonSR and 5% PEG 6000 are best suited to be used for colon targeting of diclofenac sodium.
Authors and Affiliations
Ch. Taraka Ramarao*1, B. Srinivasa Rao2, Prof. J. Vijaya ratna2
Keywords
Related Articles
- EP ID EP330608
- DOI -
- Views 91
- Downloads 0
FORMULATION DEVELOPMENT AND EVALUATION OF SUBLINGUAL FILM OF RESPERIDONE.
Abstract The aim of formulation of fast dissolving sublingual film of Risperidone was to provide quicker onset of action in short duration of time and in addition to provide immediate action after administration of dosag...
IDENTIFICATION AND MANAGEMENT OF POSTRPARTUM WOMEN ASSOCIATED WITH PSYCHIATRIC COOMORBIDITY AND ASSESSING THE EFFECTIVENESS OF MANAGEMENT
Postpartum psychiatric disorders are the common conditions that are frequently missed by health care team but have significant negative impact on parenting capacities which in turn results in negative outcome of child co...
NANO-ENCAPSULATION OF POLYPHENOL COMPOUNDS: A REVIEW
23 NANO-ENCAPSULATION OF POLYPHENOL COMPOUNDS: A REVIEW Varsha K.P*, K Krishnakumar, Dineshkumar B* Dept. of Pharmaceutics, St James College of Pharmaceutical Sciences, Chalakudy, Kerala. St James Hospital Trust Pharmace...
GREEN SYNTHESIS OF ZINC OXIDE NANOPARTICLES USING RUBIA CORDIFOLIA ROOT EXTRACT AGAINST DIFFERENT BACTERIAL PATHOGENS
Abstract Wide application of nanoparticles stimulates the need for synthesizing them But, the conventional methods are usually hazardous and energy consuming. This lead to focus on “green synthesis”of nanoparticles which...
DEVELOPMENT AND VALIDATION UV SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF ATENOLOL IN PURE MATERIALS AND PHARMACEUTICAL DOSAGE
Abstract The current research aimed to develop and validate a simple, accurate and sensitive analytical method using spectrophotometer device in assaying raw material of atenolol and determination the content of atenolol...