Development of Lacidipine loaded nanostructured lipid carriers (NLCs) for bioavailability enhancement
Journal Title: International Journal of Pharmaceutical and Medicinal Reserach - Year 2014, Vol 2, Issue 2
Abstract
Nanostructured Lipid Carriers (NLCs) are new generation Nanoparticle system, which have shown a lot of advantages over conventional Solid lipid nanoparticles, such as improved drug incorporation and release properties. The purpose of this study is to prepare an optimized nanostructured lipid carrier formulation for “Lacidipine”, and to estimate the potential of NLCs as an oral drug-delivery system. In this work, solvent injection technique was used to prepare Lacidipine–loaded NLCs. The Lacidipine loaded NLCs showed smooth surface with spherical morphology under scanning electron microscope (SEM) and transmission electron microscope (TEM) analysis. The maximum encapsulation efficiency observed was 92.65±0.5%.In In-Vitro release study, Lacidipine loaded NLCs exhibited a sustained release profile of Lacidipine and no burst release was shown. The oral bioavailability study was performed by using Wistar Albino rats. The relative bioavailability of Lacidipine loaded NLCs wasfound to be 3.9. In conclusion, the NLC formulation significantly improved the oral bioavailability of Lacidipine and revealed a positiveaspect for oral delivery of poorly watersoluble drugs.
Authors and Affiliations
Kush Anuradha, Senthil Kumar M
Keywords
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