Development and Evaluation of Bisoprolol Loaded Biolayers using Biomaterial obtained from fruit pulp of Citrus maxima
Journal Title: International Journal of Pharmaceutical and Medicinal Reserach - Year 2014, Vol 2, Issue 5
Abstract
In the present research work biomaterial from the fruit pulp skin of C. maxima was isolated and evaluated for its film forming capacity. C. maxima was isolated by an economic method and subjected to various physical evaluation parameters. The biomaterial was subjected to spectral studies like IR, 1H NMR and DSC analysis. Bisoprolol loaded biolayers were prepared using the isolated biomaterial and other co- processing agents. The prepared biolayers were evaluated for their film parameters and subjected to in-vitro drug release studies. The results were compared with the standard HPMC film. The experimental results revealed that the prepared biolayers possessed good folding endurance with appreciable release characteristics. The best film formulation was BC6 with percentage cumulative drug release of 92.73% over 35 minutes. Hence it clearly indicated that the isolated biomaterial possessed inbuilt filmability.
Authors and Affiliations
Abhishek Bansal, N. V. Satheesh Madhav, A. K Sharma
Keywords
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