Evaluation of the Genotoxic and Antigenotoxic Potential of Plantago major Methanolic Extract
Journal Title: International Journal of Pharmaceutical and Medicinal Reserach - Year 2016, Vol 4, Issue 5
Abstract
Plantago major L. (Plantaginaceae) is a perennial herb with rosette of leaves found throughout India and widely utilized traditional medicine of Indian-Ayurvedic and Chinese-medicine system. The present study was conducted to evaluate the in vivo genotoxic and/or antigenotoxic potential of P. major methanolic extract (PmME) using Organization for Economic Co-operation and Development (OECD) guidelines. The genotoxic and antigenotoxic potential of PmME was assayed using the comet assay on lymphocyte, the micronucleus (MN) and chromosomal aberration (CA) tests in bone marrow cells of albino mice. The results exhibited that none of the tested doses of PmME demonstrated genotoxic effects by the comet test, or clastogenic effects of the MN test. On the other hand, for all cells evaluated, the three tested doses of the PmME promoted inhibition of DNA damage induced by cyclophosphamide. Based on these results, it was concluded that PmME contains no genotoxic or clastogenic effects in our experimental conditions. However, it showed a significant decrease in DNA damage induced by cyclophosphamide. These findings therefore suggest that the antigenotoxic properties of PmME may be of great pharmacological importance and safe to use as an immunomodulatory agent.
Authors and Affiliations
Sanjeev Karmakar, Danswrang Goyary, Aadesh Upadhyay, Dhruba Kumar Jha, Pronobesh Chattopadhyay
Keywords
Related Articles
- EP ID EP31529
- DOI -
- Views 338
- Downloads 1
In-Vitro Cytotoxicity Study of Some Indigenous Medicinal Plants on Vero Cell Line
The ethno botany and ubiquitous plants as a source of medicine has been an important component of the health care system providing a rich resource for natural drug research and development. Natural products from medici...
The Prevalence of Hepatitis B among Medical Students, Majmaah University, Kingdom of Saudi Arabia
Background: Medical students in the course of their clinical work are at risk of acquiring hepatitis B virus (HBV) infection or transmitting it to their patients. HBV immunization for medical students in Saudi Arabia is...
Normative data of distance covered, heart rate, blood pressure and rate of perceived exertion during 6 minute walk test on 20 meter long corridor among smokers
Background-According to American Thoracic Society, the standardized length of corridor for conducting a 6 Minute Walk Test is 30 meter & it avoids the use of shorter corridor, since subject is required to take more tur...
Antimicrobial activity and phytochemical analysis of ethanolic extracts of twelve medicinal plants against oral micro organisms
The present study was carried out to evaluate the phytochemical and antimicrobial activity of twelve medicinal plants against five microbial strains causing oral infections. The antimicrobial activity of ethanolic e...
Prescription Monitoring of drugs used for asthma and COPD: A retrospective, before-after study
Background: Nowadays there is increase in the incidence of chronic diseases such as bronchial asthma and chronic obstructive pulmonary disease. As these diseases require long-term treatment, irrational use of drugs may...