Preparation and evaluation of methyl salicylate counter- Irritant emulgel of mefenamic acid
Journal Title: International Journal of Pharmaceutical and Medicinal Reserach - Year 2013, Vol 1, Issue 1
Abstract
Topical delivery of hydrophobic drug with good patient acceptance is a big challenge which is successfully handled by Emulgels. The objective of the study was to prepare emulgel of mefenamic acid, a NSAID, using Carbopol 934P as a gelling agent and methyl salicylates as counter irritant agent. Theemulsion was prepared and it was incorporated in gel base in the ratio of 1:1. The prepared six formulations were evaluated for rheological studies, spreading coefficient studies, bioadhesion strength, in vitro release and ex vivo release studies. From the obtained results it can be concluded that topical emulgel of Mefenamic acid possess great suitability for topical delivery.
Authors and Affiliations
Vivek P. Chavda, Jitendra Patel, Kaushik Parmar, Sanjay Nakum, Moinuddin M. Soniwala, Jayant R. Chavda
Keywords
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