Anti-Diabetic potential of Girardinia heterophylla in alloxan induced rat model
Journal Title: International Journal of Pharmaceutical and Medicinal Reserach - Year 2016, Vol 4, Issue 2
Abstract
Diabetes mellitus is the most common and significant chronic endocrine disorder affecting approximately 200 million individuals worldwide. The current availability of allopathic medicines is not giving optimum response to cure these conditions. In this regard researchers are trying their best to resolve this worsen condition. The present study was designed as phytochemical and pharmacological investigation of bipolar solvent extracts of Giardinia heterophylle leaves in Alexon induced diabetic rats’ model. The fresh shade dried leaves extracts were subjected to qualitative chemical tests like steroids, triterpenoids, carbohydrates, glycosides etc. and the result was found to be presence of sterol, triterpinoids, carbohydrate, tannins and phenolic compounds. The presence of steroids was confirmed by TLC & HPTLC. The effect of different extracts such as ethanolic, petroleum-ether, aqueous and chloroform of Girardinia heterophylla leaves were evaluated for their anti-diabetic activity by using alloxan induced diabetes model (albino rats) and Glibenclamide (10 mg/kg. p.o.) used as standard drug. LD50 cut-off dose for Girardinia heterophylla leaves extracts of petroleum ether, ethanolic, chloroform and aqueous extracts were found to be 2000 mg/kg. 1/10th of this lethal dose of leaves extracts i.e. 200 mg/kg body eight was taken for screening of antidiabetic potential. The experimental results confirms that ethanolic, aqueous and chloroform extracts showed significant improvement in diabetic animals.
Authors and Affiliations
Surendra Singh Gusain, Kumud Upadhyaya
Keywords
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