Polymeric systems as controlled release drug products: A review
Journal Title: International Journal of Pharmaceutical and Medicinal Reserach - Year 2014, Vol 2, Issue 2
Abstract
The use of various new techniques and therapeutic systems to obtain a controlled drug release in microbial infections is a more and more exploited approach in the modern pharmaceutical technology. Growing interest in this field arises successfully on the one hand from the often unsuccessful research for effective and non-toxic new drugs and the other hand from new knowledge of the biochemical events around and inside infected tissue cell or organ. Following administration leads to distribution of active ingredient over the entire body and reaches not only the target cells, tissues or body parts but also interacts with healthy cells. This leads to toxicities and low therapeutic efficiency, and prompts the search for novel t erapeutic strategies. Various new techniques have been explored, including conjugates obtained by linking drugs to various natural and synthetic polymers (macromolecular pro-drugs), liposome’s, nanoparticles, micro particles , drug antibody conjugates as well as various pro-drug concepts. Unfortunately some of these systems have disappointed early expectations. Therefore a strong interest was developed in the potentially promising drug delivery systems, and polymeric carrier’s electrostatically linked to the drug. This review is an attempt to understand the role of biopolymers and polymeric systems in targeted and controlled drug delivery.
Authors and Affiliations
Abu bakar, Ujjwal Nautiyal, M Senthil Kumar, Bharat Bhusan
Keywords
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