Pioneering and Encouraging Approach Mucoadhesive Drug Delivery System
Journal Title: International Journal of Pharmaceutical and Medicinal Reserach - Year 2017, Vol 5, Issue 3
Abstract
A Propitious Novel Drug delivery method, Mucoadhesive drug delivery system considerably increase dosage form residence time, furthermore augmenting the affinity with the tissue and localizing the drug in a specific region. Mucoadhesive materials are used as therapeutic agents nevertheless act security blanket to damaged tissues (such as gastric ulcers or lesions of the oral mucosa) or act as lubricating agents (in the oral cavity, eye etc).The article exemplify the mechanism by which mucoadhesion can adhere to a mucous membrane with respect to the nature of the adhering surfaces and the forcing to generate a intimacy between them. Mucosal adhesion is suffixed with various theories comprising of electronic, adsorption, wetting, diffusion, fracture and mechanical. Stages of mucoadhesion include contact stage and consolidation stage. Physiology of mucous membrane, Factors affecting mucoadhesion and Chemical bonds of mucosa interaction, ionic bonds, covalent bonds, Van-der-Waal bonds and hydrogen bonds.
Authors and Affiliations
Harvinder Kaur Saini, Ujjwal Nautiyal
Keywords
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