Development of methods for identification and assay of Himopiron
Journal Title: Фармацевтичний журнал - Year 2014, Vol 6, Issue 6
Abstract
For medicines implementation to medical practice, their quality-control techniques developed are required to produce analytical and regulative documentation in accordance with existing current demands. The aim of the study was the development of methods of identification and quantitative estimation techniques for substances Himopiron. As the object of the investigation chromatographically pure sample of substance. Identification of the examined substance was carried out by physical and chemical (NMR 1Н and IR-spectroscopy) methods which let to get full information on the chemical nature of the substance. For quantitative evaluation of the substance Himopiron, the technique of the acid-based titration of the substance was proposed in the non-water medium. To prevent additional errors, standardization of the solution titrated and quantitative measurement are conducted in the same conditions. Based on the quantitation results obtained, the limits for the main compound's quantity in the substance were defined Himopiron – 99,5–100,5%.
Authors and Affiliations
Natalia BEREZNYAKOVA
Keywords
Related Articles
- EP ID EP592887
- DOI -
- Views 68
- Downloads 0
Synthesis and structural features of 5-(4-(tert-butyl) phenyl)-4-((R)amino)-4H-1,2,4-triazole-3-thiols
Chemistry of heterocyclic compounds is one of the most popular sector in organic chemistry. Scientists allocate among them a class of derivatives of 1,2,4-triazole. This class of compounds attracts attention his broad sp...
Development solid dosage forms – suppositories with ambrosia and study their physico-chemical and technological properties
The study of technological properties of suppositories with ambrosia. It is shown how to affect the solubility of active substances and the size of their molecules for therapeutic activity. The structural and mechanical...
Scientific and methodological approaches to the assessment of intellectual potential of domestic pharmaceutical companies
Currently, the state and effectiveness of intellectual resources management system define competitiveness, strategic position and prospects of the development of modern pharmaceutical companies. The aim is to study scie...
Comparative analysis of topical dermatologic drugs with corticosteroids in the markets of Ukraine and Russian Federation
One of the most top medical and social problems of contemporaneity is spreading of skin inflammatory diseases of. Main place in the treatment of dermatological diseases takes topical dermatological therapy, by using drug...
The substantiation of plant raw materials ratio and determination of raw materials technological parameters in the development of complex tincture for the telogen effluvium treatment
Telogen effluvium is the most common form of diffuse alopecia in women due to concomitant somatic pathology and adverse exogenous factors. Pharmacotherapy of the disease requires the use of active substances that should...