The substantiation of plant raw materials ratio and determination of raw materials technological parameters in the development of complex tincture for the telogen effluvium treatment
Journal Title: Фармацевтичний журнал - Year 2015, Vol 6, Issue 6
Abstract
Telogen effluvium is the most common form of diffuse alopecia in women due to concomitant somatic pathology and adverse exogenous factors. Pharmacotherapy of the disease requires the use of active substances that should affect the various links of the pathological process. We selected plant raw materials for composition of the complex tincture intended for telogen effluvium topical treatment: nettle leaves, sage leaves and chestnut leaves. Plant raw materials contain the complex of biologically active substances (organic acid, organic silicon compounds, chlorophyll, essential oils, flavonoids, coumarins etc.), which stimulate local blood circulation, exhibit regenerative, anti-inflammatory, anti-microbial effect. So that in the herbal medicinal development is important to find the optimal composition and the plant raw materials ratio, where active substances will affect the different pathogenetic processes. Therefore, on the first phase of our research we selected plant raw materials for the complex tincture technology which contains nettle leaves, sage leaves and chestnut leaves. The purpose of this work was to find the optimal plant raw materials ratio in the complex tincture for telogen effluvium treatment and research plant raw materials technological parameters. The component ratio of the herbal composition was determined on the basis of pharmaco-therapeutic and phyto-chemical design, taking into account the contribution of each component in the final therapeutic effect of complex tincture. Determination of the main technological parameters of plant raw materials (moisture content; true, volume and bulk density; shrinkage ability, porosity, the free volume of the layer) was carried out according to the techniques of State Pharmacopeia and reference materials. On the basis of the proposed methodology was chosen the plant raw materials quantitative ratio of the complex tincture: Urtica dioica L. leaves – 5 parts, Salvia officinalis L. leaves – 3 parts, Aesculus hippocastanum L. leaves – 2 parts. Technological parameters (moisture content; true, volume and bulk density; shrinkage ability, porosity, the free volume of the layer) were studied which will allow to estimate consumption norms of raw materials and extractants, the necessary volume of extractors into the ongoing development of complex tincture technology.
Authors and Affiliations
M. I. Fedorovska, L. L. Sokolova, N. P. Polovko
Keywords
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