Development of methods of quality control for stomatologic films containing chlorhexidine, metronidazole and glucosamine
Journal Title: Фармацевтичний журнал - Year 2016, Vol 3, Issue 3
Abstract
Because of extensive grafting of inflammatory periodontal diseases in the population of different age groups the development of new prolonged combined dental medicines in the form of periodontal films is extremely important. But the new combination of active ingredients and the dosage form is a need to develop new methods of quality control. The purpose of this work was the development of methods of qualitative and quantitative analysis of glucosamine, chlorhexidine and metronidazole consisting in polymer based periodontal films. As methods of quality control for periodontal films were used spectrophotometry in ultraviolet region for chlorhexidine bigluconate, нigh performance liquid chromatography for glucosamine hydrochloride, thin-layer chromatography and нigh performance liquid chromatography for metronidazole. As a result of research methods of qualitative and quantitative analysis of glucosamine hydrochloride, chlorhexidine bigluconate and metronidazole consisting in stomatological films have been developed and the reproducibility of these methods has been confirmed. Content of active pharmaceutical ingredients in followed periodontal films complies with norms of tolerance ± 10% (content of metronidazole is 0,079 ± 0,001 mg/sm2, content of chlorhexidine bigluconate is 0,08 ± 0,002 mg/sm2, content of glucosamine is 0,5 ± 0,015 mg/sm2).
Authors and Affiliations
L. L. Davtyan, A. S. Voronkina, O. V. Chubenko, V. V. Trohimchuk
Keywords
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