Development of methods of quality control for stomatologic films containing chlorhexidine, metronidazole and glucosamine
Journal Title: Фармацевтичний журнал - Year 2016, Vol 3, Issue 3
Abstract
Because of extensive grafting of inflammatory periodontal diseases in the population of different age groups the development of new prolonged combined dental medicines in the form of periodontal films is extremely important. But the new combination of active ingredients and the dosage form is a need to develop new methods of quality control. The purpose of this work was the development of methods of qualitative and quantitative analysis of glucosamine, chlorhexidine and metronidazole consisting in polymer based periodontal films. As methods of quality control for periodontal films were used spectrophotometry in ultraviolet region for chlorhexidine bigluconate, нigh performance liquid chromatography for glucosamine hydrochloride, thin-layer chromatography and нigh performance liquid chromatography for metronidazole. As a result of research methods of qualitative and quantitative analysis of glucosamine hydrochloride, chlorhexidine bigluconate and metronidazole consisting in stomatological films have been developed and the reproducibility of these methods has been confirmed. Content of active pharmaceutical ingredients in followed periodontal films complies with norms of tolerance ± 10% (content of metronidazole is 0,079 ± 0,001 mg/sm2, content of chlorhexidine bigluconate is 0,08 ± 0,002 mg/sm2, content of glucosamine is 0,5 ± 0,015 mg/sm2).
Authors and Affiliations
L. L. Davtyan, A. S. Voronkina, O. V. Chubenko, V. V. Trohimchuk
Keywords
Related Articles
- EP ID EP565544
- DOI -
- Views 70
- Downloads 0
Marketing analysis of some groups antidiabetic medicines, presented at pharmaceutical market of Ukraine
The scarcity of state resources, the social economic and demographic situation, the deterioration of health status of population require new state approaches of organizing medical and pharmaceutical provision for the po...
Conceptual foundations of pharmacoeconomic analysis of prevention technologies of chronic viral infections
The introduction of various technologies for the prevention of chronic viral infections into practice requires well-founded evidence of their effectiveness, which can be obtained using pharmacoeconomic methods and models...
Research of plant mixtures of raspberries (Rubus idaeus L.) leaves
One of the most actual problem of modern pharmaceutical chemistry is standardization of herbal raw materials and improvement of methods of quality control multicomponent herbal medicines. A promising way to improve stand...
Development of small mekhanikal device stoimprove the process of obtaining dental medicinal films in extemporal productions
One of the problems of standardization of medicinal dental films provided a method of manufacturing irrigation is the use forms for irrigation of clearly specified parameters geometric dimensions relative 10,0 x 60,0 mm...
The analysis modern trends of social and effective organization of pharmaceutical provision to rural population in Ukraine
In Ukraine, the pharmaceutical provision of the rural population, which is about 31% in the total population of the country, requires a qualitatively new approaches taking into account the social orientation of the pharm...