Development of methods of quality control for stomatologic films containing chlorhexidine, metronidazole and glucosamine
Journal Title: Фармацевтичний журнал - Year 2016, Vol 3, Issue 3
Abstract
Because of extensive grafting of inflammatory periodontal diseases in the population of different age groups the development of new prolonged combined dental medicines in the form of periodontal films is extremely important. But the new combination of active ingredients and the dosage form is a need to develop new methods of quality control. The purpose of this work was the development of methods of qualitative and quantitative analysis of glucosamine, chlorhexidine and metronidazole consisting in polymer based periodontal films. As methods of quality control for periodontal films were used spectrophotometry in ultraviolet region for chlorhexidine bigluconate, нigh performance liquid chromatography for glucosamine hydrochloride, thin-layer chromatography and нigh performance liquid chromatography for metronidazole. As a result of research methods of qualitative and quantitative analysis of glucosamine hydrochloride, chlorhexidine bigluconate and metronidazole consisting in stomatological films have been developed and the reproducibility of these methods has been confirmed. Content of active pharmaceutical ingredients in followed periodontal films complies with norms of tolerance ± 10% (content of metronidazole is 0,079 ± 0,001 mg/sm2, content of chlorhexidine bigluconate is 0,08 ± 0,002 mg/sm2, content of glucosamine is 0,5 ± 0,015 mg/sm2).
Authors and Affiliations
L. L. Davtyan, A. S. Voronkina, O. V. Chubenko, V. V. Trohimchuk
Keywords
Related Articles
- EP ID EP565544
- DOI -
- Views 68
- Downloads 0
Spectrophotometric determination of sotalol in tablets
In this investigation a visible spectrophotometric method for the determination of sotalol based on the absorbance of colored product of the reaction between sotalol hydrochloride and bromcresol purple in acetone medium...
Synthesis and physicochemical properties 4-((R))amino)-5-methyl-4H-1,2,4-triazole-3-thiols
Purposeful synthesis of derivatives of 1,2,4-triazole is one of the most important branches of modern pharmaceutical science Modern pharmaceutical market of domestic medicines requires constant updates of existing range...
Antioxidant properties of hidazepam and amitriptyline with pain syndrome of rats
Peroxide modification of cell biostructures and functions due to the activation of free radical oxidative processes underlies the pathogenesis of a significant number of diseases different in its etiology. The ability of...
Analysis of combined cream with antifungal activity in terms of «microbiological purity»
According to GMP requirements, quality control of medicinal products justifies their safety and effectiveness from the development and production to the consumer. One of the important parameters in the development of a n...
Lipid peroxidation of rats’ heart with hypertension after nebivolol applying
A significant contribution to the study of the complex mechanisms of the action of beta-blockers may provide the investigation of structure of the heart – the main target organ of hypertension. Recent works have shown th...