Research for sele ction the solubilizers for evelopment vaginal gel with thistle’s oil
Journal Title: Фармацевтичний журнал - Year 2016, Vol 1, Issue 1
Abstract
Gynaecological diseases of bacterial and fungal nature with inflammatory and erosive processes remain a topic issue in the current gynaecology. The main direction of the treatment is the antimicrobial therapy which mainly does not lead to a desired results and impacts negatively on a disturbed microbiological balance in vagina. Therefore, it is reasonable to apply a complex therapy, affecting the all chains of pathological process that will let to decrease a period of recovery and to prevent the spread of relapses. The aim of the work was to experimentally substantiate a choice of solubilizer, determination of necessary concentration, mode and conditions of its introduction into gel basis. Examples have been studied of vaginal gel which consists of Silybum marianum's oil as a reparant and antioxidant. Research have been conducted on a model examples with concentration of Silybum marianum's oil 1%. As solubilizers, polyethyleneglycol-40 hydrogenated castor oil and Polysorbate-80 in a range of 0,25–1,0% have been applied. Motivation for the use of a solubilizer in hydrophilic gel caused by the need of oil dissolving, and thus by assurance of this system's stability. The choice of solubilizers is based on the values of hydrophilic-lipophilic balance, which high indices let to use PEG-40 hydrogenated castor oil and Polysorbate-80 as components that raise oil solubility. The experimental examples have been prepared by the way of gel basis' stirring with a combination of oil and solubilizer, by using the stirrer POLYTRON 2500 E with frame attachment. Stirring has been carried out at 100 rpm in standard conditions and with different time (15 and 30 min respectively). The obtained examples have been analyzed in terms of uniformity, colloidal and thermal stability. Fractions have sized up by means of optical microscopes Olympus BX51 and NikonEclipse E200, supplied with digital cameras КолирView II, added to a computer. Based on conducted research, the solubilizer PEG-40 hydrogenated castor oil has selected in a concentration of 1%. The examples N 4 а, 8 а were visually homogeneous, sustained experiments for colloidal and thermal stability. The oil drops quite good solubilized and distributed in hydrophilic gel. On the grounds of conducted research, as a solubilizer the following was selected: solubilizer PEG-40 hydrogenated castor oil in a concentration of 1%, which displayed the most signified solubilizing properties and ensuring maximum dispersion of the oil particles and the even distribution in a phaze of hydrophilic gel.
Authors and Affiliations
M. L. Bavykina, L. I. Vyshnevska, V. A. Megalinsky
Keywords
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