DEVELOPMENT OF MUCOADHESIVE CHITOSAN-BASED DRUG DELIVERY SYSTEM
Journal Title: Progress on Chemistry and Application of Chitin and its Derivatives - Year 2018, Vol 0, Issue
Abstract
Chitosan is a highly versatile biopolymer characterised by low toxicity, biocompatibility, and slow but complete biodegradation in the human body, possessing multiple reactive groups. One of the most well-known properties of positively charged chitosan derivatives is their ability to bind mucous membranes. The aim of this work was the analysis of mucoadhesion of unmodified 20 kDa chitosan and its hydrophobic (HC) and hydrophobic quaternised (QHC) derivatives in vitro and ex vivo. Unmodified chitosan formed large aggregates in vitro in keratinocyte and colon cell cultures and ex vivo in murine small intestine and muscle explants. At the same time, HC and especially QHC bound cells in vitro and ex vivo in a fine dotted manner, as evidenced by confocal microscopy. Such a pattern of hydrophobic derivatives distribution provides the possibility to develop mucoadhesive drug delivery systems with increased local drug release and improved chitosan biodegradation.
Authors and Affiliations
Mariya Konovalova, Balzhima Ts. Shagdarova, Anastasia A. Zubareva, Alexander Generalov, Maria Grechikhina, Elena Svirshchevskaya
EFFECT OF IONIC CROSSLINKING ON DENSITY OF HYDROGEL CHITOSAN MEMBRANES
Ionically crosslinked chitosan membranes were prepared and their density was determined using modified pycnometer method. High‑molecular compound: sodium alginate (NaAlg) and low‑molecular compounds: pentasodium tripolyp...
CHARACTERISATION OF CHITOSAN/HYALURONIC ACID BLEND FILMS MODIFIED BY COLLAGEN
In the present study, thin films based on the blends of chitosan (Ch) and hyaluronic acid (HA) with and without collagen (Coll) were characterised using tensile tests, attenuated total reflectance Fourier transform infra...
INFLUENCE OF A POLYVINYL ALKOHOL AND DEXTRANE ON THE PROPERTIES OF HYDROPHILIC GELS CONTAINING LACTIC ACID COMPLEX WITH CHITOSAN
The investigated preparations on methylcellulose base revealed good adhesion to the vaginal mucosa and were present on it throughout the daily activities of the patient. This property enabled the continuity of 24-hour ac...
THE INFLUENCE OF SUBSTRATE COMPOSITION ON THE PHYSICOCHEMICAL PROPERTIES OF HYDROGELS WITH CHITOSAN
The aim of the study was to evaluate the effect of Carbopol 934 P and PVP K 90 on the rheological properties of chitosan gels. Hydrogels were prepared with hydrocortisone containing chitosan, Carbopl 934P, PVP, propylene...
LARGE SIZE DNA IN VITRO AND IN VIVO DELIVERY USING CHITOSAN TRANSFECTION
In modern medicine, many diseases can be treated using gene therapy, which requires a DNA delivery system to prevent DNA from degradation and to transport it to the cells. Liposomal reagents are expensive for such a ther...