Development of New Spectrophotometric Methods for the Determination of Perindopril in Pharmaceutical Dosage Forms
Journal Title: International Journal of Novel Trends in Pharmaceutical Sciences - Year 2012, Vol 2, Issue 1
Abstract
Three simple and sensitive Spectrophotometric methods have been developed for the determination of Perindopril (PDL) in pure and pharmaceutical dosage forms. Method A is based on the formation of Ion-assosiation complex of the drug with Bromothymol Blue (lmax: 415 nm). Method B is based on the formation of charge transfer complex of the drug with chloranilic acid (lmax: 580 nm). Method C is based on oxidation of the drug under alkaline conditions by oxidizingagents like potassium permanganate and subsequent formation of cherry red colored chromogen (lmax : 609 nm). These methods have been statistically evaluated and found to be precise and accurate
Authors and Affiliations
CH. V Suresh, G Vidya Sagar
Keywords
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