DEVELOPMENT OF POLOXAMER BASED THERMOSENSITIVE IN SITU OCULAR GEL OF BETAXOLOL HYDROCHLORIDE
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 6
Abstract
Objective: This work was conducted to develop and evaluate Poloxamer 407-HPMC K50M based in situ gelling formulation of Betaxolol Hydrochloride (0.25%w/v) for enhancing its ocular bioavailability and sustained topical drug delivery for the treatment of glaucoma.Methods: The formulation were prepared by cold method and was investigated for their physicochemical properties like, pH, drug content, sol–gel transition temperature, gelling capacity, rheological properties and in vitro permeation across goat cornea was done and compared with a commercial eyedrop.Results: It was found that physicochemical properties of Betaxolol in situ gels were affected by formulation compositions. Increment of poloxamer 407 content decreased sol–gel transition temperature and increases the viscosity of the formulations. In this study, HPMC K50 M affect sol–gel transition temperature and viscosity but it did not affect transparency and pH of the formulation.Conclusion: In conclusion, the in vitro release studies indicated that the poloxamer-HPMC solution had the better ability to retard drug release than the commercial eyedrop over an 8 hr period.Â
Authors and Affiliations
Harish Dinkar Bachhav, Anand Savkare, Ritesh Karmarkar, Diliprao Derle
Keywords
Related Articles
- EP ID EP578704
- DOI -
- Views 63
- Downloads 0
MEMBERSHIP RATE, PERCEPTION AND AWARENESS OF THEIR PROFESSIONAL ASSOCIATION AMONG NEWLY LICENSED PHARMACISTS
Objectives: The Malaysian Pharmaceutical Society (MPS) is the professional association for pharmacists in Malaysia. It plays a significant role in the continuous education of pharmacists by serving as a platform to infor...
PROTECTIVE ROLE, IN -VITRO FREE RADICAL SCAVENGING ACTIVITIES OF ALANGIUM SALVIFOLIUM (LINN) AGAINEST CCL4 INDUCED HEPATIC DAMAGE IN RATS
Many hepatoprotective herbal preparations have been recommended in an alternative system of medicine for the treatment of hepatic disorders. There are few or no systemic studies have been done on the protective efficacy...
A STUDY ON THE PREVALENCE AND SEVERITY OF POSSIBLE DRUG-DRUG INTERACTIONS IN PEDIATRICS DEPARTMENT AT AN INDIAN TERTIARY CARE TEACHING HOSPITAL
Objective: To study the prevalence and severity of possible drug-drug interactions in the department of pediatrics.Methods: Case records of the in-patients of the pediatrics department from the medical records department...
EFFECT OF A PARTICLE ENGINEERING PROCESS ON POLYMORPHIC TRANSITION OF PYRAZINAMIDE
Objective: The objective of this work was to investigate the effect of processing on physicochemical properties of spray dried Pyrazinamide. Methods: Pyrazinamide was spray dried using several spray drying conditions, FT...
EXTRACTION AND CHARACTERIZATION OF IRAQI ARTEMISIA DRACUNCULUS DRIED AERIAL PARTS EXTRACT THOUGH HPLC AND GC-MS ANALYSIS WITH EVALUATION OF ITS ANTITUMOR ACTIVITY AGAINST 7, 12-DIMETHYLBENZE (a) ANTHRACENE INDUCED SKIN CANCER IN MICE
Objective: This study focused on the extraction of bioactive constituents in Iraqi cultivated Artemisia dracunculus L dried aerial parts and phytochemical screening with qualitative estimation of three important flavonol...