EFFECT OF A PARTICLE ENGINEERING PROCESS ON POLYMORPHIC TRANSITION OF PYRAZINAMIDE
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 2
Abstract
Objective: The objective of this work was to investigate the effect of processing on physicochemical properties of spray dried Pyrazinamide. Methods: Pyrazinamide was spray dried using several spray drying conditions, FTIR, XRD and thermal analysis were undertaken for all samples. A comparison of crystalline/amorphous nature of the starting material as well as processed materials was carried out.Results: The unprocessed material was a typical crystalline material composed of a mixture of alpha and gamma polymorphic forms of pyrazinamide.In contrast spray dried materials showed other mixtures of different polymorphs of  pyrazinamide based on spray drying conditions. In other words, the solid state of spray dried material was dependent on processing parameters (solvent systems, inlet temperature), which may indicate the effect of processing conditions on the solid state of Pyrazinamide.Conclusion: Processing of Pyrazinamide without excipients gave different polymorphs, according to the solvent mixture used in the spray drying processÂ
Authors and Affiliations
Shadeed Gad
Keywords
Related Articles
- EP ID EP579138
- DOI -
- Views 82
- Downloads 0
MICROWAVE IRRADIATED “GREEN BIGINELLI REACTION†EMPLOYING APPLE, POMEGRANATE AND GRAPE JUICE AS ECO-FRIENDLY REACTION MEDIUM
Objective: The main objective of this work is to explore the utility of apple, pomegranate and grape juice as an eco-friendly reaction medium for microwave assisted green Biginelli reaction.Methods: A series of Biginelli...
NUTRACEUTICAL APPLICATION AND VALUE ADDITION OF BANANA (MUSA PARADISICA L. VARIETY “BHUSAWAL KELIâ€) PEEL: A REVIEW
Musa paradisica L. (Musaseae) has been used in many cultures for prevention and treatment of a wide number of health disorders such as inflammation, diabetes, diarrhea, dental plaque etc. Banana popularity is on the rise...
EVALUTION OF ANTIARTHRITIC ACTIVITY OF LEAF EXTRACTS OF PERGULARIA DAEMIA [FORSK] PLANT IN EXPERIMENTAL ANIMALS
Objective: Pergularia daemia [Forsk] has been used from the long time in traditional medicine. The main objective of this work is to evaluate anti-rheumatic activity of leaf of Pergularia daemia [Forsk]Methods: Anti- art...
DEVELOPMENT OF STABILITY INDICATING RP-HPLC METHOD FOR THE DETERMINATION OF RELATED SUBSTANCES IN ATORVASTATIN SOLID DOSAGE FORM AND BULK DRUGS
Objective: The present paper reports the development of simple, rapid, accurate and stability indicating reversed phase high-performance liquid chromatography method (RP-HPLC) for estimation of related substances in Ator...
EVALUATION OF ANTI-OBESITY EFFECT OF AQUEOUS EXTRACT OF MUCUNA PRURIENS SEEDS ON RATS
Objective: Evaluation of the anti-obesity effect of aqueous extract of Mucuna pruriens seeds on rats.Methods: Male Sprague-Dawley (SD) rats were subjected to high-fat diet (HFD) for 12 wk. L-DOPA (12.5 mg/kg, p. o.) as s...