DEVELOPMENT OF SUSTAINED RELEASE NANOCAPSULES OF CATECHIN RICH EXTRACT FOR ENHANCED BIOAVAILABILITY
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 11
Abstract
Objective: The aim of the study was to develop sustained release nanocapsules of catechin rich extract (CRE) using Eudragit L 100 as a polymer by emulsion solvent evaporation technique with a major focus on enhancing its bioavailability.Methods: CRE and the polymer were subjected for physical compatibility studies using Fourier transform infrared spectroscopy (FT-IR). Nanoparticles were evaluated for percentage yield, drug (catechin) entrapment efficiency and further characterized by scanning electron microscopy (SEM),X-Ray diffraction (XRD) and differential scanning calorimetric (DSC) studies. The in vitro release study was carried out for 12 hours at pH 6.8 and pH 7.4 and the results obtained were fit to kinetic models. Concentration of residual methanol was determined by Gas chromatography (GC).Results: All prepared particles were spherical, non-porous and were in nano-meter range (50-160 nm). The XRD and DSC results suggest that CRE existed in amorphous state in the nanoformulations. The results of in vitro release study for nanocapsules showed the highest drug release of 97.27 % at pH 6.8 (NF1 nanoformulation-1) and low of 67.60 % was observed for (NF3 nanoformulation-2)atpH 7.4. The in vitro release data of nanoformulations showed the highest correlation for Higuchi matrix and Korsmeyer-Peppas, which indicated that drug release occurred via fickian diffusion mechanism. Concentration of methanol, which was used as solvent for the formulation of nanoparticles, was well within the permitted levels, suggesting the safety for oral application.Conclusion: Based on the results, it may be worth to consider further studies on catechinnanoformulations for pilot studies, in vivo studies for clinical application.Â
Authors and Affiliations
Monika Prakash, Basava Raj B V, Chidambara Murthy K. N Kottamballi Nagendra Murthy, Ahalya Naidu, Kruthi Gurudev
Keywords
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