DEVELOPMENT OF THE COMPOSITION AND TECHNOLOGY OF EXTEMPORANEOUS SUPPOSITORIES WITH СLINDAMYCIN AND SEA BUCKTHORN OIL
Journal Title: Annals of Mechnikov Institute - Year 2019, Vol 0, Issue 2
Abstract
Introduction. Antibacterial therapy certainly plays an important role in the treatment of these pathologies, although in most cases it causes allergic states, antibiotic resistance of various types of microorganism strains, and also a disfunction of normal vaginal biocoenosis. Anti-protozoal, antibacterial and antifungal agents are preferred, namely, ternidazole, metronidazole, fluconazole, clindamycin, miconazole, clotrimazole, nystatin, isoconazole etc. among the synthetic drugs used in gynecological practice. Prospective plant medicines for solving this problem are essential oils (tea tree, sea buckthorn, wormwood, chamomile), which provide inhibition of the development of pathogenic anaerobes. The aim of the work was to substantiate the composition and development of technology of combined vaginal suppositories (pessaries) with clindamycin phosphate and sea buckthorn oil for the treatment of infectious-inflammatory gynecological diseases. Materials and methods. Model samples of suppositories were prepared with 0.100 g of clindamycin phosphate and 0.500 g of sea buckthorn oil. Disperse system of suppositories with clindamycin and sea buckthorn oil is an emulsion of 1st type, therefore it is possible to use as emulsifiers the following substances: polysorbate-80, emulsion wax or alkaline soaps. Model samples of suppositories with clindamycin phosphate and sea buckthorn oil were checked by pharmaco-technological parameters (description, homogeneity, disintegration time, pH). The study of antibacterial properties of suppository model samples with clindamycin and sea buckthorn oil was carried out. Results and discussion. Samples of suppositories with polysorbate-80 become homogeneous and meet the requirements of the SPhU 2.0. The results of the conducted researches of pharmaco-technological parameters shown that model samples of suppositories with clindamycin phosphate and sea buckthorn oil meet the requirements of the SPhU 2.0 for the following parameters: description, homogeneity, disintegration time, pH. Conclusions. The composition and technology of suppositories with clindamycin phosphate and sea buckthorn oil for pharmacy preparation was developed. A technological instruction for the pharmacy preparation of suppositories has been developed and tested in the conditions of pharmacy.
Authors and Affiliations
V. M. , Chushenko, T. G. , Yarnykh, T. P. , Osolodchenko, G. B. , Yuryeva, I. V. Herasymova
Keywords
Related Articles
- EP ID EP613712
- DOI 10.5281/zenodo.3265068
- Views 168
- Downloads 0
ANTIBACTERIAL ACTIVITY OF PHYTOSUBSTANTS FROM VACCINIUM VITIS-IDAEA LEAVES
The purpose of the work is to study the antibacterial activity of phytosubstances from Vaccinium vitis-idaea leaves. Materials and methods. The objects of the study were 13 phytosubstances, obtained from Vaccinium vitis-...
STUDY OF THE INFLUENCE OF PHARMACEUTICAL FACTORS ON THE OPTIMIZATION OF THE RELEASE OF BIOLOGICALLY ACTIVE SUBSTANCES UPON RECEIPT THE WATER EXTRACTS FROM GYNECOLOGICAL PLANT MEDICAL COLLECTION
Introduction. Infusions are water extracts that do not require either sophisticated equipment or expensive or scarce extractants. From a biopharmaceutical point of view, aqueous extracts provide good availability of drug...
PRIMARY MICROBIOLOGICAL SCREENING OF AMINO ACIDS AND THEIR MODIFIED VARIANTS
The primary microbiological screening of 20 native amino acids and 52 modified variants thereof was carried out. A significant antimicrobial activity was established for synthetic derivatives against reference strains of...
ANTIMICROBIAL ACTIVITY OF EXTRACTS OF IRIS HUNGARICA AND IRIS SIBIRICA
Introduction. Referring to the latest data, infectious diseases command a large part of among the total number of pathologies in the world and are an important problem in medicine. The leading role in prevention and trea...
DETERMINATION OF VAGINAL GEL COMPOSITION ON THE BASIS OF BIOPHARMACEUTICAL AND RHEOLOGICAL RESEARCHES
Aim. The aim of the work is to determine the content of gelling agent in the composition of the vaginal gel for the treatment of urogenital symptoms during the period of women's hormonal instability and to determine the...