DEVELPOMENT AND EVALUATION OF SUSTAINED RELEASE FORMULATIONS OF VENLAFAXINE HYDROCHLORIDE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 5
Abstract
In the present study, Venlafaxine was chosen as a model drug which is a Anti-Depressant. Because of its short life (5-11hr) and its high water solubility it was chosen as a suitable candidate for sustain matrix tablet formulation. It was formulated in to matrix tablet using hydrophilic polymer such as HPMC, Eudragit RS100, and Ethyl cellulose as releases retardants. All the precompressional parameters were found to be within the standard limits. Tablets were evaluated for hardness, friability, thickness, drug content, in-Vitro release, swelling and stability studies. The effect of polymer concentration binary polymer mixture and wet granulation method on drug release profile was studied. It was absorbed that the type of polymer and its concentration has influence the drug release from matrix tablet. Matrix tablet content a blend of HPMC and ethyl cellulose successfully sustained the release of Venlafaxine for a period of 17hr. Precompressional parameter indicated that granules used for preparing tablets with free flowing. Post-copmressional parameters were within the acceptable limit. The concentration of Venlafaxine was kept constant, lactose used as filler. The sustained release from ethyl cellulose and HPMC was due to interaction between ethylcellulose chain ionic polymer and HPMC chain, non-ionic polymer, which resulted in favorable increase in the water uptake capacity and gel viscosity, leading to better control over the release of Venlafaxine F4 showed the sustained release of Venlafaxine as desired. The study revealed that the ethyl cellulose and HPMC can be used for the formulation of sustained release matrix tablet of Venlafaxine.
Authors and Affiliations
Sreenivasa rao, Sunita Jadhav , Prakash Patil , B. U. Dattatraya
Keywords
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