Dexamethasone Implant in Patients with Diabetic Macular Edema Resistant to Anti-VEGF Therapy
Journal Title: TÜRK OFTALMOLOJİ DERGİSİ - Year 2019, Vol 49, Issue 2
Abstract
Objectives: To investigate the efficacy of single dose intravitreal dexamethasone implant in patients with diabetic macular edema (DME) resistant to anti-VEGF therapy. Materials and Methods: Twenty eyes of 14 patients (8 male, 6 female; mean age, 65±5.7 years) with DME resistant to intravitreal ranibizumab injections were studied. A single intravitreal dexamethasone implant was injected into each eye and patients were followed up for 6 months. Response to therapy was assessed monthly by measuring intraocular pressure (IOP), best-corrected visual acuity (BCVA), and central foveal thickness (CFT). Results: Baseline (before injection) IOP was 14.9±2.7 mmHg and did not change significantly in the six months following injection. Baseline BCVA was 1.04±0.35 LogMAR and improved to 0.86±0.31 at month 1 without statistical significance (p=0.056). CFT was significantly lower in all monthly measurements compared to its baseline value of 682.2±229.2 μm. During the follow-up period, endophthalmitis, significant cataract, or rhegmatogenous retinal detachment were not detected. Conclusion: Intravitreal dexamethasone implant injection is associated with significant CFT reduction for up to six months without causing any complications. Although BCVA did not improve in parallel with the CFT reduction, intravitreal dexamethasone implant should be considered as an effective and safe treatment option in the management of DME patients resistant to anti-VEGF injections.
Authors and Affiliations
Serhad Nalçacı, Cezmi Akkın, Filiz Afrashi
Keywords
Related Articles
- EP ID EP551357
- DOI 10.4274/tjo.galenos.2018.84665
- Views 114
- Downloads 0
Current Management and Treatment of Dry Eye Disease
A better understanding of the pathophysiology and etiology of dry eye disease leads to more efficient management and treatment of the disease process. However, there is substantial variation among both clinicians and cou...
Contrast Sensitivity in Microtropic and Anisometropic Eyes of Successfully Treated Amblyopes
Objectives: To assess and compare contrast sensitivity function in the previously amblyopic and non-amblyopic “normal” eyes of patients with microtropia and anisometropia who achieved 20/20 visual acuity after occlusion...
Effects of Congenital Ocular Toxoplasmosis on Peripheral Retinal Vascular Development in Premature Infants at Low Risk for Retinopathy of Prematurity
Congenital toxoplasmosis and retinopathy of prematurity (ROP) are two devastating clinical entities of the newborn. There is little information in the literature about the interaction between congenital infections and re...
Yaşa Bağlı Maküla Dejenerasyonunda İntravitreal Anti-Vasküler Endotel Büyüme Faktörü Tedavisine Hastaların Uyumunu Etkileyen Faktörler
Amaç: Yaş tip yaşa bağlı maküla dejenerasyonunda (YBMD), intravitreal anti-vasküler endotel büyüme faktörü (VEGF) tedavisi uygulanan hastaların tedaviye uyumlarını etkileyen faktörlerin belirlenmesidir. Gereç ve Yöntem:...
Factors Affecting Contrast Sensitivity in Healthy Individuals: A Pilot Study
Objectives: To determine the demographic and ocular features affecting contrast sensitivity levels in healthy individuals. Materials and Methods: Seventy-four eyes of 37 subjects (7-65 years old) with refractive errors l...