Dexmedetomedine-As an Adjuvant to Epidural Analgesia: Comparison Between Different Doses
Journal Title: Journal of Pain & Relief - Year 2018, Vol 7, Issue 2
Abstract
Background: Epidural analgesia offers superior pain relief and early mobilization, especially when a local anesthetic [LA] dose is combined with an adjuvant vs. an LA alone. Objective: The current study compares the analgesic and anesthetic efficiency of dexmedetomidine (1 and 2 μgkg-1) and levobupivacaine, as well as their respective side effects. Materials and methods: This study was conducted on a total of 60 ASA I-II patients aged between 20 and 70 years, who underwent elective lower limb operations. The patients that received 1 μgkg-1 dexmedetomidine plus levobupivacaine were assigned to Group 1 (n=30) and those that received 2 μgkg-1 dexmedetomidine plus levobupivacaine to Group 2 (n=30). Results: Group 2 showed a significantly shortened onset time of sensory block, time needed for maximum sensory level and prolonged duration of anesthesia. Postoperatively, the total dose of levobupivacaine used was significantly lower, patients experienced a higher level of sedation and postoperative analgesia. However, Bradycardia and hypotension were more pronounced in Group 2 patients. Conclusion: Dexmedetomedine 2 μgkg-1 as an adjuvant to epidural analgesia significantly prolonged the duration of anesthesia and provided excellent sedation and postoperative analgesia. Therefore, higher doses of epidural dexmedetomedine are recommended in long surgical operations to avoid delayed motor recovery, bradycardia and hypotension.
Authors and Affiliations
Maged L Boules
Keywords
Related Articles
- EP ID EP580479
- DOI 10.4172/2167-0846.1000310
- Views 61
- Downloads 0
Neuralgic and Nociceptive Pain in the Knee as a Cause of the Treatment Failure after Cartilage Repair Surgery: Two Case Reports
Objective: Cartilage injuries are one of the most frequent causes of knee pain. Other causes such as meniscus tears, synovial plica, synovitis, partial and total ligament ruptures are rather easy to identify by standard...
Dexmedetomedine-As an Adjuvant to Epidural Analgesia: Comparison Between Different Doses
Background: Epidural analgesia offers superior pain relief and early mobilization, especially when a local anesthetic [LA] dose is combined with an adjuvant vs. an LA alone. Objective: The current study compares the anal...
Real-World Evidence for the Widespread Effects of Fixed-Site High- Frequency Transcutaneous Electrical Nerve Stimulation in Chronic Pain
The prevalence of chronic pain among adults in the U.S. is 30% [1], at an annual economic cost of $600 billion [2]. Many people with chronic pain also have debilitating comorbidities including low quality sleep, anxiety,...
TAP Blocks: A Recent Review of Anesthetic Combinations
Multimodal analgesia is an approach to optimize pain relief by treating pain through several mechanisms along multiple sites of the nociceptive pathway. This approach not only improves pain, but also patient satisfaction...
Is Paravertebral Block More Effective in Thoracotomy Patients Compared to Thoracic Epidural Block?
Purpose: Paravertebral block (PVB) is a simple and safe technique that can be more efficacious than epidural block (EPB) in controlling postoperative pain. We aimed to confirm this by comparing the two methods in patient...