Dexmedetomidine versus Esmolol to attenuate the extubation response following surgeries under general anaesthesia - A comparative study
Journal Title: Medpulse International Journal of Anesthesiology - Year 2019, Vol 10, Issue 2
Abstract
Background: Extubation of trachea always brings about acute, transient, undesirable hemodynamic and airway response which is sometimes fatal in susceptible patients. To attenuate this undesirable extubation response Dexmedetomidine and esmolol have been used. In present study we have compared the efficiency of two drugs in attenuation of hemodynamic and airway response during tracheal extubation. Methods: A Prospective, randomized, double blinded controlled study was carried in our hospital, After obtaining ethical clearance and written informed consent from the patients, 100 patients aged 18-50 years of ASA 1 and ASA 2 were randomly allocated into 2 groups. Group D received 1mcg/kg of dexmetomidine over 10 mins prior to extubation. group E received 1.5mg/kg of esmolol 2mins prior to extubation. Results: significant attenuation of hemodynamic and airway reflexes observed ingroup D when compared to group E. Conclusion: When compared to Esmolol (1.5mg/kg), Dexmedetomidine(1mcg/kg) effectively suppresses cough and attenuates hemodynamic responses to tracheal extubation without causing clinically significant delayed emergence.
Authors and Affiliations
G Amarappa, Balaraju Thayappa C, Rajesh S B, Meghana Mishra, Sai Mahesh Kuntrapaka
Keywords
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- EP ID EP589655
- DOI 10.26611/10151024
- Views 164
- Downloads 0
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