Di-Mercapto-Succinic Acid (DMSA) Combination with L-Carnitine Oral Supplementation Enhance the Functional Hemoglobin Derivatives in Heavy Metal Chelation Therapy
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 3
Abstract
The aim of this work was to study to what extend application of L-carnitine can enhance the hemoglobin different derivatives concentration in heavy metal intoxication status. Forty-eight New Zealand albino rabbits weighing between 2.5 and 3 kg were conducted to the study. Study was approved from the NRC, Ethical Committee. Animals were subdivided into four groups. Control group: animals did not receive neither lead ions in water nor L-carnitine administration. Group 1: animals received lead ions for 21 days as lead acetate in drinking water. Group 2: animals received lead ions for 21 days as lead acetate in drinking water and then received DMSA as a chelator of lead ions for 15 days. Group 3: animals received lead ions for 21 days as lead acetate in drinking water and then received DMSA as a chelator of lead ions for 15 days concomitant with L-carnitine powder (1000 mg) for two weeks. Hemoglobin derivatives concentration were evaluated in both groups spectrophotometrically and then by solution of linear equations. Results revealed a statistical improve in oxygenated hemoglobin derivative-oxyhemoglobin, and also showed a dramatic decrease in oxidized form of hemoglobin that is called methemoglobin after usage of L-carnitine as a supplement.
Authors and Affiliations
Bassem M. Raafat, Saad S. Al-Shehri, Alamri S. , Alaa Shafie, Ghada M. Nabil
Keywords
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- EP ID EP548105
- DOI 10.21276/ijmrp.2017.3.3.052
- Views 98
- Downloads 0
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