Diabetic Dyslipidaemia and Hypolipidaemic Effect of Turmeric in Alloxan-Induced Diabetic Rats Original Research Article
Journal Title: Isra Medical Journal - Year 2018, Vol 10, Issue 2
Abstract
OBJECTIVES: To determine serum lipid lowering effect of turmeric in alloxan-induced diabetic rats. STUDY DESIGN: A Randomized controlled trial (experimental animal study) PLACE AND DURATION: Conducted at Postgraduate Medical Institute Lahore. Approval from ethical committee of animal sciences of PGMI was obtained before the start of experiment. The study was conducted from 1st September to 30th December, 2014, after induction of diabetes. METHODOLOGY: In this study alloxan (intraperitoneal, 150mg/kg body weight) was used to produce animal models of type-I diabetes. The study was conducted on forty five albino rats. Animals were divided into three groups with fifteen animals each (normal control group A, diabetic untreated group B and diabetic group C treated with turmeric powder). Turmeric was given daily orally through 5cc disposable syringe (oral gavage method)in a dosage of 300mg/kg body-wt. dissolved in 4 ml distilled water per rat to all the 15 group C diabetic albino rats following one week after induction of diabetes. Blood samples of animals were taken from the saphenous vein after overnight fasting at zero day (one week following induction of diabetes in groups B and C), by the end of 8th week and by the end of 12th week respectively. Serum lipid profile was measured by direct quantitative method by using the commercially available Human kits. Analysis of data was done by using SPSS version 18.0. RESULTS: Significantly elevated serum lipid levels (diabetic dyslipidaemia) were found in diabetic animals of group B and C after alloxan administration. Administration of turmeric for 12 weeks to group C diabetic animals showed significant improvements in serum lipid levels towards normal but not completely. CONCLUSION: Diabetes induces significant alterations in serum lipid profile. Turmeric powder possesses hypolipidaemic effects. KEY WORDS: Diabetes Mellitus, Diabetic Dyslipidaemia, Alloxan, Turmeric HOW TO CITE THIS: Latif J, Mukhtar S, Niaz S. Diabetic Dyslipidaemia and Hypolipidaemic Effect of Turmeric in Alloxan-Induced diabetic rats Original Research Article. Isra Med J. 2018; 10(2): 81-85.
Authors and Affiliations
Javaria Latif
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