Diagnosis of Multidrug Resistant Tuberculosis by MGIT 960 at Tertiary Care Hospital
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 4
Abstract
Introduction: MDR–TB is emerging as life threatening condition and lack of proper and accurate diagnostic tools can have very severe consequences. A study is needed to find the prevalence of MDR-TB using MGIT 960 in this particular area. Aims and Objectives: To find the prevalence of MDR-TB cases in suspected tuberculosis patients. Materials And Methods: 107 samples were collected from patients with clinically suspected tuberculosis visiting microbiology department, RIMS, Ranchi, between the period of January 2017 to November 2017. After sample processing was done, it was inoculated in MGIT 960 system for culture. Growth positive samples were tested to differentiate Mycobacterium Tuberculosis Complex from Mycobacterium other than tuberculosis (MOTT) by BD ID strip test. Antimicrobial susceptibility testing was done by SIRE and PZA susceptibility testing. Results: Among 107 cases, 49 cases were growth positive, out of which 41 were Mycobacterium Tuberculosis Complex (MTbC) and 08 were MOTT. Among the MTbC cases 68.29% were male and 31.70% were female. Among 41 MTbC positive cases 31.71 % were both Isoniazid and Rifampicin resistant (MDR-TB). Maximum resistance was found against Isoniazid, 41.46%. MDR-TB was more associated with previously treated patients (treated for > 01 month), 15.71%. Conclusion: Multidrug resistant TB is emerging in India at an alarming rate. Hence, it is important to use diagnostic methods using MGIT 960 as it has higher sensitivity. The appropriate diagnosis of tuberculosis and resistance pattern can aid in usage of suitable drugs and treatment of MDR-TB cases and thereby reduce the overall morbidity and mortality due to tuberculosis.
Authors and Affiliations
Manish Kumar Sinha, Manoj Kumar, Ashok Kumar Sharma, Ashwini Verma, Amber Prasad
Keywords
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- EP ID EP534219
- DOI 10.21276/ijmrp.2018.4.4.008
- Views 104
- Downloads 0
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