Diagnostic evaluation of pancytopenia - a prospective institutional study in North East India
Journal Title: International Journal of Medical Research and Review - Year 2016, Vol 4, Issue 9
Abstract
Introduction: Pancytopenia, the simultaneous reduction of all the three formed elements of blood, is diverse in its etiology. Full clinico-hematopathological work up is crucial in each case. This study was undertaken with the objectives of identifying the causes of pancytopenia and its phenotypic characteristics in relation to age, sex, ethnicity and socio- economic status. Methods: Ninety two cases of pancytopenia studied here were diagnosed by complete hemogram study in automated hematology analyzer. Peripheral blood smear studies were carried out. All cases were subjected to bone marrow aspiration/ imprint smear cytology and trephine biopsy study. Hypoplastic anemia cases were investigated for paroxysmal nocturnal hemoglobinuria (PNH) with flow cytometric analysis of red blood cells treated with CD55 and CD59 antibodies. Results: Fifty eight percent of cases were males and mean age was 52 years. Children constituted 16% of patients. Thirty-seven percent of cases belonged to tribal community. Around 70% belonged to low socio-economic status. Causes of pancytopenia detected were primary hematological malignancies (Total 39.2 % with acute leukaemia 35.9%, lymphoma 2.2% and multiple myeloma 1.1%), hypoplastic anaemia (28.3%), myelodysplastic syndrome (MDS) (21.7%), megaloblastic Anemia (6.5%) and hypersplenism (4.3%). No PNH clone was detected amongst hypoplastic anemia cases. Conclusion: It is concluded that pancytopenia often is the manifestation of serious disease-processes and the commonest cause, in our population of this North-Eastern state of Tripura, being acute leukemia. Bone marrow cytology and biopsy study must be performed in all cases of pancytopenia to find out the cause in order to institute an early treatment.
Authors and Affiliations
Abhijit Datta, Alpana Banerjee, Arunabha Dasgupta, Debashis Nath, Nath D
Keywords
Related Articles
- EP ID EP231001
- DOI 10.17511
- Views 132
- Downloads 0
Pulmonary function, white blood corpuscles & haemoglobin levels in asymptomatic light smokers and non-smokers
Context: Smoking, a risk factor for several diseases has also been reported as the largest preventable cause of morbidity and mortality globally. Tobacco smoking is associated with a decrease in lung function in smokers...
To compare the outcome of local infiltration of corticosteroid and percutaneous release of pulley in treatment of trigger finger
Background: Stenosing tenosynovitis of fingers is one of the common tendinopathy attended in orthopaedic practice. A number of methods have been described for the treatment of this problem. Treatment ranges from conserva...
Clinical profile of mortality predictors in Leptospirosis:a prospective study in a tertiary care center
Aims and Objectives: To look for mortality predictors of Leptospirosis, with specific importance given to oli-guric renal failure and hypotension as possible predictors.Materials and Methods: A Prospective Cohort study c...
Relation of elevated serum adenosine deaminase levels to glycated hemoglobin and serum uric acid in type 2 diabetes mellitus
Background: Adenosine deaminase (ADA) is suggested to be an important enzyme for modulating the bioactivity of insulin, but its clinical significance in Type 2 diabetes mellitus is not yet established. The present study...
Comparison of triple phase ct and ultrasonography findings for evaluation of hepatic lesions
Background: Characterizing a hepatic lesion as benign or malignant is essential for correct therapeutic plan and surgical triage. USG plays major role in screening of a liver lesion. Conventional CT with only portal veno...