Diagnostic significance of various cytomorphological features and their quantification for the diagnosis of papillary carcinoma thyroid on fine needle aspiration cytology
Journal Title: Indian Journal of Pathology and Oncology - Year 2018, Vol 5, Issue 3
Abstract
Introduction The relative reliability of the morphological features for making a diagnosis of PTC when considered independently is debatable Quantification of morphological features has been attempted to improve the diagnostic efficacy of FNA thyroid but universal acceptance is lackingAim This study was aimed to analyze the independent diagnostic significance of the four common morphological featuresNuclear grooves NG Intranuclear cytoplasmic inclusions INCI Papillary Fragments and Metaplastic Cytoplasm in thyroid swellings using a quantitative approachMaterials and Methods Retrospective study including thyroid FNA cases with corresponding histopathological report was analyzed Eighty six cases had at least one of the four morphological features mentioned The cases with NG were categorized into three groups 20 1019 and Results The sensitivity specificity PPV and NPV of NG for PTC in the category of 20 was 533 982 941 and 797 respectively and the same in the category of 10 were 667 75 588 and 808 respectively Specificity and sensitivity of Frequent INCI were 100 and 3667 respectivelyConclusion Typical morphological features of PTC can be seen in nonmalignant conditions as well Occurrence of NG 20 and INCI 5 are highly specific for the diagnosis of PTC Cases with NG between 1019 should be considered as suspicious for malignancy and pathologist should cautiously look for other morphological features Keywords Papillary carcinoma thyroid PTC FNAC Cytology Morphology Quantification
Authors and Affiliations
Chetna Sharma, Babu Jacinth, Vijayakumar Harivanzan
Keywords
Related Articles
- EP ID EP475943
- DOI 10.18231/2394-6792.2018.0094
- Views 55
- Downloads 0
Adenocarcinoma of intestinal type arising in mature cystic teratoma of ovary in a young female: An incidental finding
Mature cystic teratoma (MCT) is commonest germ cell tumor of ovary. In 1-2% of MCTs malignant transformation is known to occur. Most of the malignancies originating from MCTs are squamous cell carcinomas and adenocarcino...
Our experience in soft tissue tumours in correlation with Immunohistochemistry: A retrospective study
Introduction: The diagnosis and classification of soft tissue sarcomas has been a source of difficulty for surgical pathologists. This has been largely attributable to a significant degree of overlap in histologic featur...
Placental pathology in low birth weight babies a prospective observational study
Introduction Low birth weight LBW babies are more common in developing countries like India The placenta is an organ which connects fetus to mother during intrauterine life Any change in the mother reflects on placenta a...
Myxoid Neurothekeoma: Report of a rare tumour at unusual site
Introduction: Neurothekeoma is a rare benign soft tissue tumor of uncertain histogenesis which affects adolescents and young adults. It is rare to find these tumors occurring in children. Neurothekeoma usually presents w...
Clinicopathological and immunohistological profile of infiltrating ductal carcinoma breast in a tertiary care centre of western UP- A study of 100 cases
Introduction Breast cancer is the most common cause of death of women worldwide and it is the most common malignancy in Indian females followed by carcinoma cervix Diagnosis involves various modalities like clinical exam...