Fine-needle aspiration cytology of granulocytic sarcoma: A cytomorphologic analysis
Journal Title: Indian Journal of Pathology and Oncology - Year 2018, Vol 5, Issue 1
Abstract
Introduction Granulocytic sarcoma is a rare extramedullary tumor comprising of immature myeloid cells in an extramedullary site which is commonly found with myeloid leukemia acute or chronic or occasionally with chronic myeloproliferaive disorders or myelodysplastic syndrome GS may also be the initial manifestation of leukemia Because of the diverse clinical presentation differentiation of Granulocytic sarcoma GS from malignant lymphomas Non Hodgkin39s lymphoma or Hodgkins lymphoma extramedullary hematopoiesis poorly differentiated carcinoma and infections is very important for cytopathologistMaterials and Methods A retrospective study of total 16 cases of GS diagnosed by FNAC 14 FNAs and 2 pleural effusion fluid specimen was done Cytology smears were examined for cytomorphology in conjunction with clinical details Depending upon the population of the cells present on the smears GS was categorized as blastic immature or mature GSResults The age of patients ranged from 8 years to 50 years with male dominance 10 males and 6 femalesThe most commonest site of aspiration was subcutaneous or soft tissue 9 cases followed by lymphnodes 4 cases and breast 1 case 2 cases of GS involving pleural fluid were also included A detailed history clinical examination and relevant investigations of patients showed that GS was secondary to acute myeloid leukemia AML in 6 patients was secondary to chronic myeloid leukemia CML in 3 patients and was secondary to juvenile myelomonocytic leukemia JMNL in one patients 6 patients were presented with concurrent myeloproliferative disorder AML in 4 patients and CMLCP in 2 patientsDepending upon the population of the cells present on the smears GS was categorized as blastic GS 7 aspirates immature GS 3 aspirates and mature GS 6 aspiratesConclusion FNAC plays important role in diagnosis of GS GS should be included in the diagnosis of undifferentiated neoplasm of the soft tissue or lymph nodes even in patients with no clinical suspicion of leukemia Detailed patients clinical history along with careful morphologic evaluation for granulocytic cell identification should helps to reach a definitive diagnosisKeywords Cytomorphology Fine Needle Aspiration Cytology Granulocytic Sarcoma
Authors and Affiliations
Chetan M. Dharaiya, Trupti S. Patel, Majal G. Shah, Jahnavi S. Gandhi
Keywords
Related Articles
- EP ID EP473177
- DOI 10.18231/2394-6792.2018.0006
- Views 50
- Downloads 0
A cytological comparison of efficacy of bronchioalveolar lavage, transbronchial needle aspiration and image guided fine needle aspiration for diagnosis of pulmonary lesions in a rural tertiary care centre
Introduction Pulmonary lesions include a wide variety of benign and malignant conditions of lung pleura mediastinum and vertebrae Lung cancer is a frequently diagnosed cancer worldwide1 Although clinical data location an...
Invasive carcinoma no special type, pleomorphic carcinoma: Case report of a rare variant of invasive breast carcinoma
Invasive breast carcinoma No special type NST Pleomorphic carcinoma is a rare morphological variant of invasive carcinoma NST This is a case report of a 30 year old nulliparous woman who presented with a tender palpable...
Myeloid sarcoma of maxillary sinus
We report a case of isolated myeloid sarcoma MS of maxillary sinus in a patient who had no evidence of leukemia at the time of diagnosis of MS A 39 year old healthy woman presented with right cheek swelling of one year d...
Correlation of p63 protein expression and Ki-67 labelling index with histological grades of meningiomas: A five years study
Introduction Meningiomas account for 1325 of primary intracranial tumours and 25 of intraspinal tumors and histological grading has prognostic and therapeutic implications However histological criteria are sometimes not...
Spectrum of breast lesions and cyto- histopathological correlation - A retrospective study in a teaching institution in North Malabar
Introduction Breast carcinoma is the most common malignancy in women Fine needle aspiration Cytology FNAC is an important component of triple approach for diagnosing breast lesions and is highly sensitive specific rapid...