Correlation of p63 protein expression and Ki-67 labelling index with histological grades of meningiomas: A five years study
Journal Title: Indian Journal of Pathology and Oncology - Year 2018, Vol 5, Issue 1
Abstract
Introduction Meningiomas account for 1325 of primary intracranial tumours and 25 of intraspinal tumors and histological grading has prognostic and therapeutic implications However histological criteria are sometimes not fulfilled to predict the biological behaviour of meningiomas necessitating use of adjunct ancillary techniques like immunohistochemical markers The aim of the study was to assess the correlation between the p63 protein expression with MIB1 labelling index in different histological gradesMaterials and Methods This was a retrospective and prospective study of patients with intracranial and intraspinal meningiomas diagnosed during the period 20092014 The H E Stained histological sections of the entire meningioma tumour were graded according to WHO 2007 criteria Immunohistochemistry was performed using p63 protein and Ki67Result The age of the patients ranged from 475 years including seven children Out of 135 cases 46 3407 cases occurred in males and the remaining 896592 cases were females There were 125 grade I 06 grade II 04 grade III meningiomas Amongst Grade I tumours n 125 16 n20 exhibited nuclear positivity for p63 proteinAmong Grade II n 06 and Grade III n 04 all showed strong immune expression for p63 Statistical significant increase in mean labelling index MIB1 was noted between Grade I to II and Grade II to IIIConclusion Increased p63 expression and Ki67 labelling index is associated more with high grade Meningioma and possible recurrenceKeywords Meningiomas MIB1 labelling index p63 protein
Authors and Affiliations
Sujani C. Madabhushi, Shrinivas B. Somalwar, S. Chandrasekar, V. Vijay Sreedhar
Keywords
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- EP ID EP473198
- DOI 10.18231/2394-6792.2018.0024
- Views 69
- Downloads 0
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