Diagnostic utility of haematological parameters and C-reactive protein in early detection of neonatal septicaemia in developing countries
Journal Title: Indian Journal of Pathology and Oncology - Year 2018, Vol 5, Issue 1
Abstract
Introduction Septicaemia is one of the major causes of mortality and morbidity during the neonatal period especially in developing countries Early diagnosis of neonatal sepsis is a diagnostic problem due to nonspecific clinical features Blood culture is the gold standard but it takes several days and is expensive Hence there is a critical need for laboratory tests that aid in the rapid diagnosis of neonatal sepsisAims and Objectives To measure the role of Haematological Scoring System and Creactive protein as an early diagnostic tool for neonatal sepsisMaterials and Methods This was a prospective study performed on 116 neonates who were clinically suspected cases of septicaemia admitted at Neonatal Intensive Care Unit Yenepoya Hospital Mangalore Each hematologic parameter like total leukocyte count polymorphonuclear neutrophil PMN count immature PMN count platelet count etc were analysed in all cases using the Haematological Scoring System 40HSS41 formulated by Rodwell et al Blood cultures were performed as a gold standard Creactive protein CRP was also estimatedResults Out of 116 neonates 6152 were male neonates and 5548 were female neonates 1815 cases were with proven sepsis 5850 cases with probable sepsis and 4035 cases were on the safer side The HSS was found to have a sensitivity of 944 specificity of 755 positive predictive value was 414 and negative predictive value was 986Conclusions HSS is a rapid simple and easily affordable screening tool for early detection of neonatal septicaemia It also provides an effective guideline to make decisions regarding judicious use of antibioticsKeywords Blood culture Haematological Scoring System Neonates Septicaemia Rapid diagnosis
Authors and Affiliations
Rakshatha Nayak, Subhan Ali R, Nisha T. G
Keywords
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- EP ID EP473194
- DOI 10.18231/2394-6792.2018.0020
- Views 58
- Downloads 0
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