Diagnostic value of Galectin-3 expression in papillary thyroid carcinoma and its variants
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2016, Vol 4, Issue 11
Abstract
Abstract: Galectin-3 is a member of beta-galectoside binding protein family and function as modulator of cell growth through galectoside-protein correlated with the occurance and diagnostic valu of papillary thyroid carcinoma (PTC). The study performed in 67 known histopathological cases of institution including neoplastic and non-neoplastic cases of thyroid. The immunohistochemistry perfomed and result showed that, cases of papillary thyroid carcinoma in spite of any variant give 2 to 3+ positive for majority of case. The other neoplastic and non-neoplastic cases which give negative or lesser positive for galectin-3 .The author conclude that galectin-3 could be a valuable antibody for diagnosis of papillary thyroid carcinoma and a potential immunomarker, in making a preoperative distinction between PTC and non-PTC patients. In addition galectin-3 may provide more significant contributions in distinguishing PTC with or without lymph node metastasis. Keywords:Galectin-3, immunohistochemisty, papillary thyroid carcinoma
Authors and Affiliations
ChumilaThinely Bhutia, Ajay Kr Singh, Raj Mehrotra, MadhuMati Goel, Malti Kumari
Keywords
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