DIAGNOSTIC VALUE OF METHODS FOR SENSITIZATION DETERMINATION IN PEOPLE WITH ALLERGIC RHINITIS (REVIEW OF LITERATURE AND OWN DAT
Journal Title: Астма и Аллергия - Year 2019, Vol 1, Issue 1
Abstract
Objective was to review the literature on the diagnostic value of various methods for determining sensitization in patients with allergies, to study the parameters of the specificity and sensitivity of skin testing and laboratory determination of specific IgE. Materials and methods. 88 patients with allergic rhinitis were examined by three different methods of specific allergic diagnosis (in vivo and in vitro) in accordance with the guidelines of the ethics committee of the National Pirogov memorial medical university, all were beyond the acute period. The inclusion criteria were allergic rhinitis diagnosis (both intermittent and persistent) with provensensitivity to domestic allergens. Skin prick test was carried out according to the classical testing procedure in accordance with regulatory documents with commercial extracts of allergens. Western blot testing for specific IgE levels was performed using RIDA qLine test systems (R-Biopharm AG, Darmstadt, Germany) and Euroline (Euroimmun). The sIgE concentration was converted to a nominal scale (grades) according to the following rules: < 0.35 IU mL-1-level 0 (negative), (0.36-0.69) IU mL-1-level 1 (boundary levels ), (0.7-3.49) IU mL-1-level 2 (slightly elevated), (3.50-17.4) IU mL-1-level 3 (moderately elevated), (17.5-49,9) IU mL-1-level 4 (high levels), (50-100) IU mL-1-level 5 (very high levels) and > 100 IU mL-1-level 6 (extremely high levels). Results and discussion.The results of two systems for determining the specific IgE to D. Pteronissinus by Rida AllergyScreen and Euroline have a systematic difference in rates (-1.27 kU / l).Between the data of skin testing with D. Pteronissinus allergens and detection of specific IgE by the Rida AllergyScreen method, there is good agreement between the results, there is satisfactory agreement between the results of the research between the data of skin testing with allergens D. Pteronissinus and the detection of specific IgE by the Euroline method.
Authors and Affiliations
A. Ye. Bogomolov
Keywords
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- EP ID EP560875
- DOI 10.31655/2307-3373-2019-1-44-49
- Views 93
- Downloads 0
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