Diarrhea in young children: clinical picture, diagnosis, principles of therapy
Journal Title: Здоров`я дитини - Year 2018, Vol 13, Issue 0
Abstract
Many diseases in infants and young children are accompanied by the development of diarrheal syndrome. As a result, there are organic lesions and functional disorders in the intestine. It is well known fact that 1.4 billion children under 5 years in the world suffer from acute diarrhea, and 123 million of them are forced to seek medical help urgently, 9 million require inpatient care, and 1.8 million children die from dehydration. In this connection, the choice of therapeutic regimen remains urgent. Medications that slow intestinal motility (loperamide) are contraindicated in acute diarrhea in children, since the risk of side effects including ileus, drowsiness, nausea (mortality to 1 %) is high. Probiotics are living microbial drugs commonly used to prevent acute diarrhea. A large number of researches have been conducted, and results of meta-analyzes have been published that have revealed the effect of Escherichia coli strain Nissle 1917 (Mutaflor) in reducing the duration of diarrhea in children with acute gastroenteritis. Escherichia coli strain Nissle 1917 is one of the three bacteria in the world, which is better characterized at the molecular-biological level, the most investigated non-pathogenic and genetically stable strain in the world with 100-year history, having a genetic map, the genome of which is completely sequenced, genetic loci are deterministic. The product is included into the German Collection of Microorganisms and Cell Cultures (DSMZ). The purpose of our study was to improve the therapeutic approaches to the correction of diarrheal syndrome using Escherichia coli strain Nissle 1917 (Mutaflor) in the main treatment regimens. Seventy four children were examined and divided into two groups: the first group — children with diarrheal syndrome, who additionally received Mutaflor from the first day, the second group — children with diarrheal syndrome, who received traditional therapy. As a result of the study, the data were obtained proving the effectiveness of Escherichia coli strain Nissle 1917 (Mutaflor) in the treatment of diarrhea in young children, its beneficial effect not only on intestinal microflora and normalization of intestinal kinetics, but also on faster improvement of clinical symptoms, which allows recommending it to children from the first months of life.
Authors and Affiliations
O. Yu. Beloysova, K. V. Savytska, N. V. Pavlenko, I. G. Solodovnichenko, A. M. Kaafarani, A. Yu. Volianskyi
Keywords
Related Articles
- EP ID EP292300
- DOI 10.22141/2224-0551.13.0.2018.13118
- Views 80
- Downloads 0
The results of prospective multicenter study of the effectiveness of amino acid formula in infants with severe atopic dermatitis and allergy to cow’s milk proteins
The article presents the main results of prospective multicenter study of effectiveness of using amino acid formula in diet therapy for the infants with severe atopic dermatitis (AD) and allergy to cow's milk protein (CM...
The Role of Growth Factors (VEGF, TGF-β1) and Cyclic Guanosine Monophosphate in the Formation of Pulmonary Hypertension in Children with Bronchopulmonary Dysplasia
In 82 children with bronchopulmonary dysplasia (from 1 to 36 months of corrected age) we investigated the level of VEGF, TGF-β1 in blood and cyclic guanosine monophosphate (cGMP) in sputum. It was revealed that children...
Prospective study on the significance of mucosal barrier dysfunction markers in assessing the effectiveness of the new strategy for treating food hypersensitivity in children
Background. Further search for the ways to correct the key links of food hypersensitivity (FH) skin symptoms remains perspective. Aim of the study was to evaluate pathogenetically grounded therapy of the skin FH symptoms...
Effect of Basic Pharmacotherapy on the State of Cerebral Hemodynamics in Children with Bronchial Asthma
The article analyzes the impact of basic pharmacotherapy on the state of extra- and intracranial cerebral hemodynamics in children with bronchial asthma (BA). Monotherapy with antileukotriene drugs normalizes the greates...
The Clinical Potential of Semisynthetic Penicillins in Acute Bacterial Otitis Media and Acute Bacterial Tonsillitis in Children in the Practice of ENT Doctor: Focus on Ospamox and Amoxsiclav®
The wide prevalence of bacterial infections of upper respiratory tract, especially in childhood, the presence of complications that threaten the health and lives of patients necessitate the prescription of a rational sys...