DICLOFENAC INDUCED ANGIOEDEMA: A CASE REPORT
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2015, Vol 8, Issue 2
Abstract
 Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly prescribed groups of drugs for variety of indications. However, theyare associated with many potential adverse drug reactions. The detailed information of these reactions is necessary to decrease the morbidity andmortality associated with these reactions. Angioedema can be caused by many etiological factors including drugs. The NSAID induced angioedemaoccurs infrequently but sometimes it may prove fatal if not treated promptly. The angioedema due to NSAIDs use may be caused due to increase inproduction of Leukotriene due block in cyclooxygenase pathway. The mast cells and to lesser extent basophils plays a major role in pathogenesis ofangioedema. Early recognition and discontinuation of responsible NSAIDs should be done. Treatment with corticosteroids and antihistaminic is usefulin management of angioedema. The author reports a case of a patient with angioedema in association with use of Diclofenac.Keywords: Angioedema, Diclofenac, Non-steroidal anti-inflammatory drugs, Leukotrienes.
Authors and Affiliations
Harshal Nutanrao Pise, Sudhir L. Padwal
Keywords
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