Dietary implication of high malondialdehyde, reduced vitamin D and total antioxidant status of prostate cancer subjects in Ibadan

Journal Title: International Journal of Biomedical Research - Year 2015, Vol 6, Issue 9

Abstract

A number of studies have investigated the roles of lipid peroxidation/ anti-oxidative balance as risk factors of prostate cancer. However, no study has yet to relate these factors with dietary habits of individuals in this environment. The objective of this study was to assess the role of lipid peroxidation and its relationship with vitamin D, calcium and dietary habits in individuals with prostate cancer. A total of sixty four (64) male participants (32 patients and 32 age-matched apparently healthy individuals as control) were recruited. Blood samples were analyzed for Malondialdehyde (MDA), Total antioxidant status (TAS), Calcium and Albumin spectrophotometrically; Prostate specific antigen (PSA) using immune radiometric assay; and Vitamin D by high performance liquid chromatography. Participants with prostate cancer had a significantly higher (p? 0.05) mean plasma level of MDA and PSA but lower TAS and vitamin D when compared with the control group. The plasma levels of MDA had a significant positive correlation with plasma PSA while negative with TAS in both groups. A significant proportion of the study participants that consumed dairy and smoked food regularly had a higher mean plasma level of MDA when compared with those that did not regularly as well as the control. This study has provided support for the hypothesis that lipid peroxidation and oxidative stress is associated with prostate cancer. A peculiar relationship exists between dairy and smoked food in prostate cancer which may be linked with increased lipid peroxidation.

Authors and Affiliations

K. S. Adedapo, T. O. Olusanya, A. O. Takure

Keywords

Related Articles

Prevalence pattern of risk factors for coronary artery disease (CAD) among patients presenting for coronary artery bypass grafting (CABG) in rural Indian population

Objectives: Coronary artery disease (CAD) is the leading cause of death worldwide. The aim of study was to identify the pattern of prevalence of risk factors in CAD patients presenting for surgical revascularization by c...

Comparison of pre-operative and post-operative astigmatism and visual acuity after pterygium excision followed by sutureless and gluefree conjunctival autograft

Objective: To compare change in refractive astigmatism and visual acuity following pterygium excision followed by sutureless and gluefree conjunctival autograft. Method: A prospective , non randomized , comparative and...

Neutral Zone- A Clinical Report

Edentulism from a long term results in high resorption of lower edentulous ridge which often pose a problem in stability of mandibular complete dentures. It is a challenge for a prosthodontist to rehabilitate those patie...

Sarcomatous lesions of Mediastinum - An unchartered territory: A tale of two case reports

Various primary and metastatic malignant lesions can occur in the mediastinumandmay cause diagnostic dilemmas in achieving definitive diagnosis. Synovial sarcoma is a malignant neoplasm predominantly affecting soft tissu...

Pan genotypic response to combination treatment with Sofosbuvir and Daclatasvir in chronic Hepatitis C patients

Background and aims: Hepatitis C is a major cause of liver related morbidity and mortality. Prevalence of HCV infection in India has been variously estimated as 0.9 to 1.9%. With the advent of DAAs, the treatment has bee...

Download PDF file
  • EP ID EP391853
  • DOI 10.7439/ijbr.v6i9.2426
  • Views 177
  • Downloads 0

How To Cite

K. S. Adedapo, T. O. Olusanya, A. O. Takure (2015). Dietary implication of high malondialdehyde, reduced vitamin D and total antioxidant status of prostate cancer subjects in Ibadan. International Journal of Biomedical Research, 6(9), 661-668. https://europub.co.uk/articles/-A-391853