Differences in participant classification and intervention effects based on HbA1C and fasting plasma glucose among a community sample of African Americans
Journal Title: Archives of Diabetes & Obesity - Year 2018, Vol 1, Issue 5
Abstract
Since 2010, the American Diabetes Association has endorsed both HbA1C (A1C) and fasting plasma glucose (FPG) to determine diabetes risk. Given the discordance between classifications based on FPG and A1C and higher A1C levels among African Americans (AAs) than whites, we sought to examine the prevalence of normoglycemia, prediabetes, and diabetes among a community sample of adult AAs (n=704) screened for enrollment in a randomized Diabetes Prevention Program (DPP). We conducted a retrospective analysis to estimate the degree of discordance between risk categories based on FPG and A1C and examine the risk factors that predicted A1C and FPG levels. To determine differential effects on risk categories defined using FPG and A1C, we examined the effects of the program on the measures at 12 weeks post-intervention among the intervention arm participants. The tests revealed different prevalence levels at baseline: A1C, 36.2% normoglycemia, 52% prediabetes and 11.8% diabetes; FPG, 81.1%, 16.8%, and 2%, respectively. There was discordance among A1C and FPG and among the risk categories (p<0.001). Both final regression models included age and waist circumference as predictors. For FPG, additional predictors were family history of diabetes and male gender. Post intervention, only those classified in the prediabetes category defined in terms of either test demonstrated intervention effects. Screening test choice results in different sample composition; both A1C and FPG respond to intervention effects among individuals classified in the prediabetes group only. These results have implications for research and clinical practice.
Authors and Affiliations
Lovoria B Williams, Jeannette O Andrews, Stephen W Looney, Andrea M Kriska, Janie Heath
Keywords
Related Articles
- EP ID EP589324
- DOI 10.32474/ADO.2018.01.000122
- Views 43
- Downloads 0
Diet, Obesity and Diabetes
Obesity and diabetes have become a very important global problem. In developed countries the incidence of both seems to have stabilised probably due to greater awareness and better education. Weight reduction in obese su...
The Prevalence of Hypothyroidism in Patients with Type 2 Diabetes Mellitus in Saudi Community based Hospital a Retrospective Single Centre Study
Background and Objective: The association between diabetes and thyroid dysfunction were studied. To estimate retrospectively the frequency of hypothyroidism in patients with type 2 diabetes (T2DM) in Saudi community-base...
Screening for Malnutrition in Older Hospitalised Patients in an Internal Medicine Department of a Greek Public Hospital
Background: Malnutrition is a major public health concern that frequently tends to be unrecognized and untreated. About 1/3 of all patients in the hospital are undernourished globally. Malnutrition is significantly more...
Evaluation of the Prevalence of Gestational Diabetes Using Fasting Blood Glucose and Glycated Heamoglobin in Yenagoa Metropolis
There is understanding that most pregnant women with gestational diabetes mellitus stands the risk of having adverse obstetric and perinatal outcome. The need for an early detection and effective management of this probl...
A Phase II Study to Evaluate Connections in Higher Risk For Heart Disease and Narcissists Appearance in Private Pharmacy Institutions Pune University India Behaviors Among Men Who Have Work With Men (MM): Is There Evidence of an Effect?
Respect can earn. Wrinkle shows life is loved your life and ageing with dignity. Self-admiration increasing day by day. According to a study conducted by the Private Pharmacy Instituions in Pune University, men women hav...