Different effects of postnatal caffeine treatment on two pentylenetetrazole-induced seizure models persist into adulthood.
Journal Title: Pharmacological Reports - Year 2013, Vol 65, Issue 4
Abstract
Postnatal treatment with caffeine from P7 to P11 (10 or 20 mg/kg daily) resulted in transient changes in two pentylenetetrazole (PTZ)-induced models of epileptic seizures characterized by spike-and-wave EEG rhythm in immature rats. To know if some changes persist into adulthood we studied these models in young adult Wistar rats.
Authors and Affiliations
Jana Tchekalarova, Hana Kubová, Pavel Mareš
Keywords
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