D-serine, a selective glycine/N-methyl-D-aspartate receptor agonist, antagonizes the antidepressant-like effects of magnesium and zinc in mice.
Journal Title: Pharmacological Reports - Year 2008, Vol 60, Issue 6
Abstract
Zinc and magnesium are potent inhibitors of the N-methyl-D-aspartate (NMDA) receptor complex. Recent data demonstrate that both zinc and magnesium, like other NMDA receptor antagonists, exhibit antidepressant-like activity in rodent screening tests and depression models. In the present study, we investigated the effect of D-serine (agonist for the glycine(B) site of the NMDA receptor complex; 100 nmol/mouse, icv) on magnesium (30 mg/kg, ip)- and zinc (5 mg/kg, ip)-induced activity during a forced swim test (FST) in mice. The antidepressant-like effect observed during FST for both ions was abolished by D-serine co-treatment. The present study indicates that the NMDA receptor complex, especially the glycine(B) site, plays a role in the antidepressant-like activity of magnesium and zinc in the FST in mice.
Authors and Affiliations
Ewa Poleszak, Bernadeta Szewczyk, Aleksandra Wlaź, Sylwia Fidecka, Piotr Wlaź, Andrzej Pilc, Gabriel Nowak
Keywords
Related Articles
- EP ID EP96819
- DOI -
- Views 71
- Downloads 0
Effect of cysteamine on bile secretion in the rat.
The effect of cysteamine, a specific somatostatin depletor, on biliarysecretion was studied in urethane-anesthetized rats. Different groups of rats received ip cysteamineat 25, 100 or 340 mg/kg just before bile collectio...
C3435T Polymorphism of the ABCB1/MDR1 gene encoding P-glycoprotein in patients with inflammatory bowel disease in a Polish population.
Background: Inflammatory bowel disease (IBD) belongs to the group of chronic diseases of the gastrointestinal tract, prevalence of which is increasing in the Polish population. The two main clinical types of IBD are ulce...
Effect of metyrapone on the fluoxetine-induced change in extracellular dopamine, serotonin and their metabolites in the rat frontal cortex.
Major depression is frequently associated with the hyperactivity of the hypothalamic-pituitary-adrenocortical axis, and glucocorticoid synthesis inhibitors have been shown to exert antidepressant action. Metyrapone (an i...
Triptolide inhibits CCR5 expressed in synovial tissue of rat adjuvant-induced arthritis.
Triptolide has been clinically used to treat patients with rheumatoid arthritis, in which chemokine receptors play an important role in immune and inflammatory responses. To investigate the effect of triptolide on CCR5,...
Identification of factors mediating the effect of the brain dopaminergic system on the expression of cytochrome P450 in the liver.
Our earlier study showed that damage to brain dopaminergic pathways causes decreases in CYP2B, CYP2C11 and CYP3A, as well as increases in CYP1A protein levels and activities in the liver. The aim of the present study was...