LPS-induced oxidative stress and inflammatory reaction in the rat striatum.
Journal Title: Pharmacological Reports - Year 2013, Vol 65, Issue 4
Abstract
Inflammation-induced microglia activation and increased oxidative stress have been observed in neurodegenerative disorders, such as Parkinson's disease. The aim of our study was to determine the appropriate dose and route of LPS administration to study hydroxyl radical generation and extracellular level of dopamine (DA), glutamate (GLU) and adenosine (ADN) in the rat striatum as markers of DA neuron damage and glial cell activation. The effect of LPS administration on DA, DOPAC, HVA and hydroxyl radical tissue level was also examined.
Authors and Affiliations
Karolina Noworyta-Sokołowska, Anna Górska, Krystyna Gołembiowska
Keywords
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