Effect of classic and atypical neuroleptics on cytochrome P450 3A (CYP3A) in rat liver.
Journal Title: Pharmacological Reports - Year 2012, Vol 64, Issue 6
Abstract
BACKGROUNd: Cytochrome P450 3A (CYP3A) subfamily is involved in the metabolism of xenobiotics (e.g., drugs) and endogenous substances (e.g., steroids). The aim of the present study was to investigate the influence of classic and atypical neuroleptics on the level and activity of CYP3A in rat liver, measured as a rate of testosterone 2β- and 6β-hydroxylation.
Authors and Affiliations
Jacek Wójcikowski, Anna Haduch, Władysława Daniel
Keywords
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