Different responses of mesenteric artery from normotensive and spontaneously hypertensive rats to nitric oxide and its redox congeners.
Journal Title: Pharmacological Reports - Year 2007, Vol 59, Issue 3
Abstract
The conversion of nitric oxide (NO.) into its congeners nitrosonium (NO(+)) and nitroxyl (HNO/NO(-)) ions may have important consequences for signal transduction and physiological responses. Manganese-containing superoxide dismutase (MnSOD) may convert NO. into its redox congeners. In our current work, we have examined the mechanism of sodium nitroprusside (SNP)-induced relaxation of arteries, with or without endothelium, from both normotensive and spontaneously hypertensive (SH) rats in the absence and presence of MnSOD. SNP induced a greater degree of relaxation in normotensive than in SH rats. MnSOD antagonized SNP-induced relaxation and effect was greater in normotensive than hypertensive rats. However, MnSOD even potentiated SNP-induced relaxation in mesenteric arteries with endothelium from SH rats. Our results indicate that HNO/NO(-)-mediated relaxation is more effective in mesenteric artery smooth muscle from SH rats than from normotensive rats and that vascular dysfunction in SH rats is not solely endothelium-derived but involves changes in vascular smooth muscles.
Authors and Affiliations
Zorana Oreščanin, Slobodan Milovanović, Snežana Spasić, David Jones, Mihajlo Spasić
Keywords
Related Articles
- EP ID EP144469
- DOI -
- Views 85
- Downloads 0
Metformin raises hydrogen sulfide tissue concentrations in various mouse organs.
Background: The epidemic of diabetes mellitus type 2 forces to intensive work on the disease medication. Metformin, the most widely prescribed insulin sensitizer, exerts pleiotropic actions on different tissues by not fu...
Biotechnology and genetic engineering in the new drug development. Part I. DNA technology and recombinant proteins.
Pharmaceutical biotechnology has a long tradition and is rooted in the last century, first exemplified by penicillin and streptomycin as low molecular weight biosynthetic compounds. Today, pharmaceutical biotechnology st...
Transforming growth factor beta and cardiovascular diseases: the other facet of the 'protective cytokine'.
Transforming growth factor beta (TGF-beta) is a cytokine engaged in a wide range of diverse and often contradictory functions. Its effect on the cardiovascular system is also ambiguous; on the one hand, there is a strong...
Expression of multiple Transient Receptor Potential channel genes in murine 3T3-L1 cell lines and adipose tissue.
Background: Calcium and its signaling have a role in adipogenesis. Transient Receptor Potential (TRP) channels are non-selective cation channels with a high permeability to calcium. Methods: In the present study the expr...
Different effects of postnatal caffeine treatment on two pentylenetetrazole-induced seizure models persist into adulthood.
Postnatal treatment with caffeine from P7 to P11 (10 or 20 mg/kg daily) resulted in transient changes in two pentylenetetrazole (PTZ)-induced models of epileptic seizures characterized by spike-and-wave EEG rhythm in imm...