Differential Association of Niemann-Pick C1 Gene Polymorphisms with Maternal Prepregnancy Overweight - Gestational Diabetes
Journal Title: Journal of Diabetes and Obesity - Year 2015, Vol 2, Issue 1
Abstract
A genome-wide association study GWAS - subsequent replication studies in diverse ethnic groups indicate that common Niemann-Pick C1 gene NPC1 polymorphisms are associated with morbid-adult obesity or diabetes independent of body weight The objectives for this prospective cross-sectional study were to determine allele frequencies for NPC1 polymorphisms 644A gt G 1926C gt G 2572A gt G - 3797G gt A - association with metabolic disease phenotypes in an ethnically diverse New Mexican obstetric population Allele frequencies for 1926C gt G 2572A gt G - 3797G gt A were significantly different between race ethnic groups non-Hispanic white Hispanic - Native American The results also indicated a significant pairwise linkage-disequilibrium between each of the four NPC1 polymorphisms in race ethnic groups Moreover the derived - major allele for 1926C gt G was associated OR 2 11 95 CI 1 10-3 96 P 0 022 with increased risk for maternal prepregnancy overweight BMI 25 0- 29 9kg m sup2 while the ancestral - major allele for 2572A gt G was associated OR 4 68 95 CI 1 23- 17 8 P 0 024 with increased risk for gestational diabetes in non-Hispanic whites but not Hispanics or Native Americans In summary this is the first transferability study to investigate common NPC1 polymorphisms in a multiethnic population - demonstrate a differential association with increased risk for maternal prepregnancy overweight - gestational diabetes
Authors and Affiliations
William S. Garver
Keywords
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- EP ID EP417821
- DOI 10.15436/2376-0494.15.007
- Views 123
- Downloads 0
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