Comparative Efficiency of Sulfonylurea and/or Dipeptidyl Peptidase-4 inhibitor in Basal-Supported Oral Therapy in Japanese Patients with Type 2 Diabetes (JDDM39)
Journal Title: Journal of Diabetes and Obesity - Year 2015, Vol 2, Issue 2
Abstract
Basal-supported Oral Therapy BOT comprising treatment with oral antidiabetic drugs and once-daily injections of a long-acting insulin analog is a convenient regimen However it sometimes fails to achieve satisfactory glycemic control because of uncontrolled hyperglycemia in the postprandial period The aim of the present retrospective cohort study was to assess the efficiency of a sulfonylurea SU and or a dipeptidyl peptidase-4 inhibitor DPP-4i on glycemic control in Japanese patients with type 2 diabetes mellitus T2DM who were receiving BOT The 243 T2DM patients who started long-acting insulin added onto an SU and or DPP-4i with or without metformin were followed-up for 6 months Mean HbA1c levels in the SU DPP-4i and SU DPP-4i groups decreased steadily from baseline by approximately 1 over the 6-month followed-up period After 6 months 57 4 51 6 and 62 2 of patients in the SU DPP-4i and SU DPP-4i groups respectively had continued on the same therapeutic regimen and 15 2 18 5 and 16 5 of patients respectively had achieved HbA1c levels lt 7 0 The efficiency of BOT with SU DPP-4i and SU DPP-4i was limited but some patients i e those with a lower body mass index and HbA1c may benefit from these BOT regimens
Authors and Affiliations
Keiko Arai
Keywords
Related Articles
- EP ID EP417830
- DOI 10.15436/2376-0949.15.030
- Views 109
- Downloads 0
Obesity and Environmental Pollutants
Obesity is a global health problem in recent years Adipose tissue was known as a storage tissue increasing with rise of the body mass index the indicator of obesity The endocrine functions of adipose tissue might contr...
Estimated Stearoyl-CoA-desaturase (SCD)-1 and Elongase of Very Long Chain Fatty Acids (Elovl) 6 Activities From Serum Fatty Acids Are Reciprocally Associated with Visceral Fat Area in Type 2 Diabetic Patients
Introduction Abdominal visceral fat accumulation can cause insulin resistance in type 2 diabetic patients We investigated the association between serum fatty acid levels and the visceral fat area VFA Materials and...
Composition Diversity and Abundance of Gut Microbiome in Prediabetes and Type 2 Diabetes
Association between type 2 diabetes (T2DM) and compositional changes in the gut micro biota is established, however little is known about the dysbiosis in early stages of Prediabetes (preDM). The purpose of this investig...
Occurrence of Left Ventricular Hypertrophy in Subjects with Metabolic Syndrome: Role of Adiponectin
This study was designed to evaluate the role of total plasma adiponectin ADPN on the occurrence of left ventricular hypertrophy in subjects with metabolic syndrome MetS compared to a control group without MetS The m...
Gut Microbiota and Glucose Homeostasis
The involvement of gut microbiota in type 2 diabetes has been recognized. Several Clostridium or lactobacilli species are reportedly enriched in type 2 diabetes. A study by Forslund et al, showed that gut microbes mediat...