Comparative Efficiency of Sulfonylurea and/or Dipeptidyl Peptidase-4 inhibitor in Basal-Supported Oral Therapy in Japanese Patients with Type 2 Diabetes (JDDM39)
Journal Title: Journal of Diabetes and Obesity - Year 2015, Vol 2, Issue 2
Abstract
Basal-supported Oral Therapy BOT comprising treatment with oral antidiabetic drugs and once-daily injections of a long-acting insulin analog is a convenient regimen However it sometimes fails to achieve satisfactory glycemic control because of uncontrolled hyperglycemia in the postprandial period The aim of the present retrospective cohort study was to assess the efficiency of a sulfonylurea SU and or a dipeptidyl peptidase-4 inhibitor DPP-4i on glycemic control in Japanese patients with type 2 diabetes mellitus T2DM who were receiving BOT The 243 T2DM patients who started long-acting insulin added onto an SU and or DPP-4i with or without metformin were followed-up for 6 months Mean HbA1c levels in the SU DPP-4i and SU DPP-4i groups decreased steadily from baseline by approximately 1 over the 6-month followed-up period After 6 months 57 4 51 6 and 62 2 of patients in the SU DPP-4i and SU DPP-4i groups respectively had continued on the same therapeutic regimen and 15 2 18 5 and 16 5 of patients respectively had achieved HbA1c levels lt 7 0 The efficiency of BOT with SU DPP-4i and SU DPP-4i was limited but some patients i e those with a lower body mass index and HbA1c may benefit from these BOT regimens
Authors and Affiliations
Keiko Arai
Keywords
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- EP ID EP417830
- DOI 10.15436/2376-0949.15.030
- Views 107
- Downloads 0
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Comparative Efficiency of Sulfonylurea and/or Dipeptidyl Peptidase-4 inhibitor in Basal-Supported Oral Therapy in Japanese Patients with Type 2 Diabetes (JDDM39)
Basal-supported Oral Therapy BOT comprising treatment with oral antidiabetic drugs and once-daily injections of a long-acting insulin analog is a convenient regimen However it sometimes fails to achieve satisfactor...